Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi
Duan, Yao-Tao1,2,4; Zhang, Juan3; Lao, Yuan-Zhi3; Tan, Hong-Sheng3; Ye, Yan-Song1,2,4; Yang, Xing-Wei1,2; Xu, Hong-Xi3; Xu, Gang1,2
2018-11-14
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume59Issue:46Pages:4067-4072
Abstract

Seven new spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperhenones G-M (1-7), were isolated from the ethyl acetate fraction of Hypericum henryi. The structures of 1-6 sharing a common octahydrospiro[cyclohexan-1,5'-indene]-2,4,6-trione core and compound 7 possessing a rare 4,5-seco spirocyclic PPAP skeleton, were elucidated on the basis of comprehensive NMR and MS spectroscopic data. The inhibitory activities of all the isolates were examined against three human tumor cell lines, and compound 9 showed week inhibitory activities to A549 and HeLa (IC50 24.8 and 27.9 mu M). In addition, compounds 4 and 9 suppressed the metastasis of A549 cell in vitro at 40 mu M. (C) 2018 Published by Elsevier Ltd.

KeywordPolyprenylated Acylphloroglucinol Hyperhenones G-m Hypericum Henryi Spirocyclic Antitumor
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/63254
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorYang, Xing-Wei; Xu, Hong-Xi; Xu, Gang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Duan, Yao-Tao,Zhang, Juan,Lao, Yuan-Zhi,et al. Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi[J]. TETRAHEDRON LETTERS,2018,59(46):4067-4072.
APA Duan, Yao-Tao.,Zhang, Juan.,Lao, Yuan-Zhi.,Tan, Hong-Sheng.,Ye, Yan-Song.,...&Xu, Gang.(2018).Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi.TETRAHEDRON LETTERS,59(46),4067-4072.
MLA Duan, Yao-Tao,et al."Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi".TETRAHEDRON LETTERS 59.46(2018):4067-4072.
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