Knowledge Management System of Kunming Institute of Botany,CAS
| Anti-hepatitis B virus effects of the traditional Chinese herb Arteinisia capillaris and its active enynes | |
Geng, Chang-An1 ; Yang, Tong-Hua1; Huang, Xiao-Yan1; Yang, Jing1; Ma, Yun-Bao1; Li, Tian-Ze1; Zhang, Xue-Mei1; Chen, Ji-Jun1,2
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| 2018-10-05 | |
| Source Publication | JOURNAL OF ETHNOPHARMACOLOGY
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| ISSN | 0378-8741 |
| Volume | 224Pages:283-289 |
| Abstract | Ethnopharmacological relevance: Artemisia capillaris (Yin-Chen) is a famous traditional Chinese medicine (TCM) for treating acute and chronic hepatitis in China. Enynes are one type of characteristic constituents in this herb, while their anti-hepatitis B virus (anti-HBV) properties have not been systemically investigated. Aim of the study: This study is to reveal the active part of A. capillaris, and systemically investigate the enynes and their anti-HBV activity. Materials and methods: The total extract and each fraction of A. capillaris were assayed for the anti-HBV activity to reveal the active part. Bioassay-guided fractionation using various chromatographic techniques yielded the enynes, whose structures were elucidated by spectroscopic analyses and ECD calculations. The anti-HBV properties inhibiting HBsAg and HBeAg secretions and HBV DNA replication were evaluated on HepG 2.2.15 cell line in vitro. Results: ACT-2 and ACT-3 was revealed to be the respective active and toxic part of A. capillaris. Twelve enynes (1-12) involving four new ones (1-4) and two unusual enyne analogs (13-14) were isolated from the active part (ACT-2). All the isolates were assayed for their anti-HBV activity, and the preliminary structure-activity relationships were summarized based on the structural features. In particular, compound 4 could significantly inhibit the secretions of HBsAg and HBeAg, and HBV DNA replication with IC50 values of 197.2 (SI > 5.1), 48.7 (SI > 20.5) and 9.8 (SI > 102) mu M. Conclusions: Enynes are responsible for the anti-HBV effects of A. capillaris. Hydroxyl and glycosyl groups are preferable for maintaining activity. This is the first time to systematically investigate the anti-HBV activity of enynes in A. capillaris, which provides valuable information for understanding the ethnopharmacological application of Yin-Chen. |
| Keyword | Artemisia capillaris Enynes Anti-HBV activity Structure-activity relationships |
| DOI | 10.1016/j.jep.2018.06.005 |
| Language | 英语 |
| WOS ID | WOS:000442333900026 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/62140 |
| Collection | 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Chen, Ji-Jun |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Geng, Chang-An,Yang, Tong-Hua,Huang, Xiao-Yan,et al. Anti-hepatitis B virus effects of the traditional Chinese herb Arteinisia capillaris and its active enynes[J]. JOURNAL OF ETHNOPHARMACOLOGY,2018,224:283-289. |
| APA | Geng, Chang-An.,Yang, Tong-Hua.,Huang, Xiao-Yan.,Yang, Jing.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2018).Anti-hepatitis B virus effects of the traditional Chinese herb Arteinisia capillaris and its active enynes.JOURNAL OF ETHNOPHARMACOLOGY,224,283-289. |
| MLA | Geng, Chang-An,et al."Anti-hepatitis B virus effects of the traditional Chinese herb Arteinisia capillaris and its active enynes".JOURNAL OF ETHNOPHARMACOLOGY 224(2018):283-289. |
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