KIB OpenIR
Total Synthesis of (-)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation
Liang, Xiao1,2; Zhang, Tian-Yuan1,2; Meng, Chun-Yan1; Li, Xue-Dan1,2; Wei, Kun1; Yang, Yu-Rong1
2018-08-03
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号20期号:15页码:4575-4578
摘要A synthetic strategy for the catalytic asymmetric total synthesis of (-)-actinophyllic acid is described. This highly efficient and enantioselective approach allows the rapid installation of the four contiguous chiral centers (C16, C15, C20, and C19) by way of a dual Ir/amine catalytic allylation of 2-indolyl vinyl carbinol 6 and an aldol reaction of resultant chiral aldehyde 4a with 2-pyrrolidinone 5. The key indo1-3-ylmethanamine moiety and 1-azabicyclo[4.2.1]nonane ring system were readily generated through a selective Mannich-like cyclization and an intramolecular N-alkylation, respectively.
资助信息Key Research Program of the Frontier Sciences of the CAS; NSFC; Government of Yunan Province
DOI10.1021/acs.orglett.8b01861
语种英语
资助项目Key Research Program of the Frontier Sciences of the CAS[QYZDB-SSW-SMC026] ; NSFC[21672224] ; NSFC[21472200] ; Government of Yunan Province[2017FA002]
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000441112700042
出版者AMER CHEMICAL SOC
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62133
专题中国科学院昆明植物研究所
通讯作者Yang, Yu-Rong
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Liang, Xiao,Zhang, Tian-Yuan,Meng, Chun-Yan,et al. Total Synthesis of (-)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation[J]. ORGANIC LETTERS,2018,20(15):4575-4578.
APA Liang, Xiao,Zhang, Tian-Yuan,Meng, Chun-Yan,Li, Xue-Dan,Wei, Kun,&Yang, Yu-Rong.(2018).Total Synthesis of (-)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation.ORGANIC LETTERS,20(15),4575-4578.
MLA Liang, Xiao,et al."Total Synthesis of (-)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation".ORGANIC LETTERS 20.15(2018):4575-4578.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liang, Xiao]的文章
[Zhang, Tian-Yuan]的文章
[Meng, Chun-Yan]的文章
百度学术
百度学术中相似的文章
[Liang, Xiao]的文章
[Zhang, Tian-Yuan]的文章
[Meng, Chun-Yan]的文章
必应学术
必应学术中相似的文章
[Liang, Xiao]的文章
[Zhang, Tian-Yuan]的文章
[Meng, Chun-Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。