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Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters
Liu, Huiying1; Zhang, Xiao1; Wu, Mingyi2; Li, Zhongjun1
2018-09-01
发表期刊CARBOHYDRATE RESEARCH
ISSN0008-6215
卷号467页码:45-51
摘要Fucosylated chondroitin sulfate (FuCS) is a structurally complex glycosaminoglycan found in sea cucumbers with a wide spectrum of biological activities, among which anticoagulant activity is particularly attractive for the development of alternative anticoagulant drugs with decreased adverse effects and risks of bleeding. Previous studies show that FuCS glycomimetics bearing several trisaccharide epitopes displayed promising anticoagulant activity and did not change the mode of action of FuCS. To simplify synthetic difficulty of high valent glycoclusters and obtain candidate compounds with relatively low molecular weights, here we report the synthesis of two FuCS glycoclusters with low valence and more compact structures. Anticoagulation studies showed that these simplified "short-armed" glycoclusters demonstrated comparable potency with "long-armed" high valent glycoclusters, offering a concise approach for the development of novel anticoagulant agents.
关键词Fucosylated chondroitin sulfate Glycocluster Glycosaminoglycan Anticoagulant Carbohydrate
资助信息National Natural Science Foundation of China
DOI10.1016/j.carres.2018.07.008
语种英语
资助项目National Natural Science Foundation of China[21472007] ; National Natural Science Foundation of China[21232002] ; National Natural Science Foundation of China[8167330]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
WOS记录号WOS:000441886200006
出版者ELSEVIER SCI LTD
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62126
专题中国科学院昆明植物研究所
通讯作者Wu, Mingyi; Li, Zhongjun
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Liu, Huiying,Zhang, Xiao,Wu, Mingyi,et al. Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters[J]. CARBOHYDRATE RESEARCH,2018,467:45-51.
APA Liu, Huiying,Zhang, Xiao,Wu, Mingyi,&Li, Zhongjun.(2018).Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters.CARBOHYDRATE RESEARCH,467,45-51.
MLA Liu, Huiying,et al."Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters".CARBOHYDRATE RESEARCH 467(2018):45-51.
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