Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity

doi:10.1021/acs.jnatprod.8b00208

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	Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity
	Bai, Wei 1; Yang, Hong-Ying 1; Jiao, Xing-Zhi 1; Feng, Ke-Na 2,3; Chen, Jian-Jun 1; Gao, Kun 1
	2018-08-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:8 页码:1777-1785
摘要	Ten new triterpenoids, ailanaltiolides A-J (1-10), and three known analogues (11-13) were isolated from the roots of Ailanthus altissima. Compounds 1-7 are apotirucallane-type, compounds 8 and 9 are tirucallane-type, and compound 10 is a trinordammarane-type triterpenoid. This is the first study indicating the genus Ailanthus as a potential source for apotirucallane derivatives, which contain an alpha,beta-unsaturated-epsilon-lactone A-ring and diversely modified C-17 side chains. Spectroscopic data interpretation, electronic circular dichroism analysis, and X-ray crystallographic data defined the structures and absolute configurations of these triterpenoids. Compounds 2, 7, and 8 showed cytotoxicity against four tumor cell lines (HeLa, 786-O, HepG2, and A549). In particular, compound 2 exhibited the highest activity against 786-O cells with an IC50 value of 8.2 mu M in vitro.
DOI	10.1021/acs.jnatprod.8b00208
语种	英语
WOS记录号	WOS:000443103700010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/62115
专题	中国科学院昆明植物研究所
通讯作者	Chen, Jian-Jun; Gao, Kun
作者单位	1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Bai, Wei,Yang, Hong-Ying,Jiao, Xing-Zhi,et al. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(8):1777-1785.
APA	Bai, Wei,Yang, Hong-Ying,Jiao, Xing-Zhi,Feng, Ke-Na,Chen, Jian-Jun,&Gao, Kun.(2018).Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity.JOURNAL OF NATURAL PRODUCTS,81(8),1777-1785.
MLA	Bai, Wei,et al."Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity".JOURNAL OF NATURAL PRODUCTS 81.8(2018):1777-1785.