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Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity
Bai, Wei1; Yang, Hong-Ying1; Jiao, Xing-Zhi1; Feng, Ke-Na2,3; Chen, Jian-Jun1; Gao, Kun1
2018-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81期号:8页码:1777-1785
摘要Ten new triterpenoids, ailanaltiolides A-J (1-10), and three known analogues (11-13) were isolated from the roots of Ailanthus altissima. Compounds 1-7 are apotirucallane-type, compounds 8 and 9 are tirucallane-type, and compound 10 is a trinordammarane-type triterpenoid. This is the first study indicating the genus Ailanthus as a potential source for apotirucallane derivatives, which contain an alpha,beta-unsaturated-epsilon-lactone A-ring and diversely modified C-17 side chains. Spectroscopic data interpretation, electronic circular dichroism analysis, and X-ray crystallographic data defined the structures and absolute configurations of these triterpenoids. Compounds 2, 7, and 8 showed cytotoxicity against four tumor cell lines (HeLa, 786-O, HepG2, and A549). In particular, compound 2 exhibited the highest activity against 786-O cells with an IC50 value of 8.2 mu M in vitro.
资助信息National Natural Science Foundation of China
DOI10.1021/acs.jnatprod.8b00208
语种英语
资助项目National Natural Science Foundation of China[31470421] ; National Natural Science Foundation of China[21778027]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000443103700010
出版者AMER CHEMICAL SOC
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62115
专题中国科学院昆明植物研究所
通讯作者Chen, Jian-Jun; Gao, Kun
作者单位1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
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Bai, Wei,Yang, Hong-Ying,Jiao, Xing-Zhi,et al. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(8):1777-1785.
APA Bai, Wei,Yang, Hong-Ying,Jiao, Xing-Zhi,Feng, Ke-Na,Chen, Jian-Jun,&Gao, Kun.(2018).Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity.JOURNAL OF NATURAL PRODUCTS,81(8),1777-1785.
MLA Bai, Wei,et al."Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity".JOURNAL OF NATURAL PRODUCTS 81.8(2018):1777-1785.
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