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Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship
Chen,Gang1; Wang,Ye2; Hao,Xiaojiang2; Mu,Shuzhen2; Sun,Qianyun2
2011-07-01
发表期刊Chemistry Central Journal
ISSN1752-153X
卷号5期号:1
摘要AbstractTo develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened. All these compounds were found to be active, and N-ethyl isatin was found with the most potent activity of 69.7% protective effect on PC12 cells. Structure-activity relationship analyses showed the bioactivity of N-alkyl isatins decline as the increasing of the chain of the alkyl group, furthermore odd-even effect was found in the activity, which is interesting for further investigation.
DOI10.1186/1752-153X-5-37
语种英语
WOS记录号BMC:10.1186/1752-153X-5-37
出版者Springer International Publishing
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61810
专题中国科学院昆明植物研究所
通讯作者Hao,Xiaojiang
作者单位1.Xi'an Shiyou University; College of Chemistry and Chemical Engineering
2.Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
推荐引用方式
GB/T 7714
Chen,Gang,Wang,Ye,Hao,Xiaojiang,et al. Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship[J]. Chemistry Central Journal,2011,5(1).
APA Chen,Gang,Wang,Ye,Hao,Xiaojiang,Mu,Shuzhen,&Sun,Qianyun.(2011).Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship.Chemistry Central Journal,5(1).
MLA Chen,Gang,et al."Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship".Chemistry Central Journal 5.1(2011).
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