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Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells
Choi,Roy Chi-Yan1; Jiang,Zhiyong1,2; Xie,Heidi Qun1; Cheung,Anna Wing-Han1; Lau,David Tai-Wai1; Fu,Qiang1; Dong,Tina Tingxia1; Chen,Jijun2; Wang,Zhengtao3; Tsim,Karl Wah-Keung1
2010-10-28
发表期刊Chinese Medicine
ISSN1749-8546
卷号5期号:1
摘要AbstractBackgroundRadix notoginseng is used in Chinese medicine to improve blood circulation and clotting; however, the pharmacological activities of other parts of Panax notoginseng have yet to be explored. The present study reports the anti-oxidative effects of various parts of Panax notoginseng.MethodsVarious parts of Panax notoginseng, including the biennial flower, stem-leaf, root-rhizome, fiber root and sideslip, were used to prepare extracts and analyzed for their anti-oxidation effects, namely suppressing xanthine oxidase activity, H2O2-induced cytotoxicity and H2O2-induced ROS formation.ResultsAmong various parts of the herb (biennial flower, stem-leaf, root-rhizome, fiber root and sideslip), the water extract of the biennial flower showed the strongest effects in (i) inhibiting the enzymatic activity of xanthine oxidase and (ii) protecting neuronal PC12 cells against H2O2-induced cytotoxicity. Only the water extracts demonstrated such anti-oxidative effects while the ethanol extracts did not exert significant effects in suppressing xanthine oxidase and H2O2-induced neuronal cytotoxicity.ConclusionsThe present study demonstrates the biennial flower of Panax notoginseng to have neuroprotection effect on cultured neurons and the underlying protection mechanism may involve anti-oxidation.
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61802
专题中国科学院昆明植物研究所
通讯作者Tsim,Karl Wah-Keung
作者单位1.Hong Kong University of Science and Technology; Center for Chinese Medicine and Department of Biology
2.Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China
3.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine
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GB/T 7714
Choi,Roy Chi-Yan,Jiang,Zhiyong,Xie,Heidi Qun,et al. Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells[J]. Chinese Medicine,2010,5(1).
APA Choi,Roy Chi-Yan.,Jiang,Zhiyong.,Xie,Heidi Qun.,Cheung,Anna Wing-Han.,Lau,David Tai-Wai.,...&Tsim,Karl Wah-Keung.(2010).Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells.Chinese Medicine,5(1).
MLA Choi,Roy Chi-Yan,et al."Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells".Chinese Medicine 5.1(2010).
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