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New Sweet-Tasting C21 Pregnane Glycosides from the Roots of Myriopteron extensum
Sun, Guo1; Zhang, Hong-Xia1; Ma, Yong-Peng1,2; Li, Ming-Xiang1,2; Du, Zhi-Zhi1
2018-07-25
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume66Issue:29Pages:7735-7739
Abstract

To investigate the sweet-tasting components in the roots of Myriopteron externum, the phytochemical study of its roots was conducted, which led to the discovery of 12 new C21 pregnane glycosides (extensumside M-X, 1 - 12) and two known ones (extensumside C and extensumside E, 13-14). Their chemical structure elucidation was accomplished by means of spectroscopic methods: IR, UV, ESI-MS, and NMR (H-1 NMR, C-13 NMR, HSQC, H-1-H-1 COSY, HMBC, HSQC-TOCSY, and ROESY), as well as the chemical evidence. Sensory analysis of these compounds revealed that nine of them (l, 3, 4, 5, 6, 7, 8, 13, and 14) are highly sweet-tasting compounds. Their sweetness intensities are 25 to 400 times greater than that of sucrose. Analysis of the structure-activity relationship (SAR) indicated that the sweet intensities of the isolated compounds are closely related to the aglycone 3 beta,l6 alpha-dihydroxy-pregn-5-en-20-one, the number and type of the monosaccharide m the sugar chain linked to C-3 and C-16 and the position of the mBe group.

KeywordNatural Sweet Molecules C21 Pregnane Glycosides Human Sensory Evaluation Sweet Intensity Myriopteron Extensum
DOI10.1021/acs.jafc.8b02348
Language英语
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61691
Collection资源植物与生物技术所级重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Sun, Guo,Zhang, Hong-Xia,Ma, Yong-Peng,et al. New Sweet-Tasting C21 Pregnane Glycosides from the Roots of Myriopteron extensum[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(29):7735-7739.
APA Sun, Guo,Zhang, Hong-Xia,Ma, Yong-Peng,Li, Ming-Xiang,&Du, Zhi-Zhi.(2018).New Sweet-Tasting C21 Pregnane Glycosides from the Roots of Myriopteron extensum.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(29),7735-7739.
MLA Sun, Guo,et al."New Sweet-Tasting C21 Pregnane Glycosides from the Roots of Myriopteron extensum".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.29(2018):7735-7739.
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