Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors
Gao, Jun-Bo1,2,3; Yang, Shuang-Jing1; Yan, Zi-Ru2; Zhang, Xing-Jie1; Pu, De-Bing1; Wang, Li-Xia1; Li, Xiao-Li1; Zhang, Rui-Han1; Xiao, Wei-Lie1,2
2018-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:4Pages:998-1006
AbstractSpecies belonging to the genus Callicarpa are used traditionally in Chinese medicine for the treatment of inflammation, rheumatism, and pain. Investigation of the leaves and twigs of Callicarpa bodinieri resulted in the isolation of nine new abietane diterpenoids, bodinieric acids A-I (1-9), along with six known compounds (10-15). The structures of 1-9 were elucidated on the basis of the interpretation of their HRESIMS and NMR data and by ECD calculations. To explore the potential therapeutic target of this plant for immune-mediated disease, the inhibitory activities of the isolates obtained were determined against 13 kinase enzymes. Eight compounds exhibited moderate inhibitory effects on spleen tyrosine kinase (SYK), and the IC50 values of compounds 2 and 6 were 7.2 and 10.7 mu M, respectively. In addition, a preliminary structure-activity relationship of this scaffold was analyzed with both molecular docking and a 3D-QSAR pharmacophore model.
DOI10.1021/acs.jnatprod.7b01082
Language英语
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61339
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Gao, Jun-Bo,Yang, Shuang-Jing,Yan, Zi-Ru,et al. Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):998-1006.
APA Gao, Jun-Bo.,Yang, Shuang-Jing.,Yan, Zi-Ru.,Zhang, Xing-Jie.,Pu, De-Bing.,...&Xiao, Wei-Lie.(2018).Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors.JOURNAL OF NATURAL PRODUCTS,81(4),998-1006.
MLA Gao, Jun-Bo,et al."Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors".JOURNAL OF NATURAL PRODUCTS 81.4(2018):998-1006.
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