| Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors | |
Gao, Jun-Bo1,2,3; Yang, Shuang-Jing1; Yan, Zi-Ru2; Zhang, Xing-Jie1; Pu, De-Bing1 ; Wang, Li-Xia1; Li, Xiao-Li1; Zhang, Rui-Han1; Xiao, Wei-Lie1,2
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| 2018-04-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| Volume | 81Issue:4Pages:998-1006 |
| Abstract | Species belonging to the genus Callicarpa are used traditionally in Chinese medicine for the treatment of inflammation, rheumatism, and pain. Investigation of the leaves and twigs of Callicarpa bodinieri resulted in the isolation of nine new abietane diterpenoids, bodinieric acids A-I (1-9), along with six known compounds (10-15). The structures of 1-9 were elucidated on the basis of the interpretation of their HRESIMS and NMR data and by ECD calculations. To explore the potential therapeutic target of this plant for immune-mediated disease, the inhibitory activities of the isolates obtained were determined against 13 kinase enzymes. Eight compounds exhibited moderate inhibitory effects on spleen tyrosine kinase (SYK), and the IC50 values of compounds 2 and 6 were 7.2 and 10.7 mu M, respectively. In addition, a preliminary structure-activity relationship of this scaffold was analyzed with both molecular docking and a 3D-QSAR pharmacophore model. |
| DOI | 10.1021/acs.jnatprod.7b01082 |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/61339 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Gao, Jun-Bo,Yang, Shuang-Jing,Yan, Zi-Ru,et al. Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):998-1006. |
| APA | Gao, Jun-Bo.,Yang, Shuang-Jing.,Yan, Zi-Ru.,Zhang, Xing-Jie.,Pu, De-Bing.,...&Xiao, Wei-Lie.(2018).Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors.JOURNAL OF NATURAL PRODUCTS,81(4),998-1006. |
| MLA | Gao, Jun-Bo,et al."Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors".JOURNAL OF NATURAL PRODUCTS 81.4(2018):998-1006. |
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