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题名: Phenolic Compounds from Belamcanda chinensis Seeds
作者: Song, Ying-Ying1, 2, 3; Liu, Ying2; Yan, Yong-Ming2; Lu, Xi-Feng2; Cheng, Yong-Xian2, 4
刊名: MOLECULES
关键词: Belamcanda chinensis ; belamcanosides A and B ; GC analysis ; HMGCR ; SQLE ; LDLR ; SORT1
英文摘要: Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (3-7), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (-)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells.
出版日期: 2018-03-01
卷号: 23, 期号:3, 页码:580
DOI标识: 10.3390/molecules23030580
语种: 英语
ISSN号: 1420-3049
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/61243
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China

Recommended Citation:
Song, Ying-Ying,Liu, Ying,Yan, Yong-Ming,et al. Phenolic Compounds from Belamcanda chinensis Seeds[J]. MOLECULES,2018,23(3):580.
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