Phenolic Compounds from Belamcanda chinensis Seeds
Song, Ying-Ying1,2,3; Liu, Ying2; Yan, Yong-Ming2; Lu, Xi-Feng2; Cheng, Yong-Xian2,4
2018-03-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:3页码:580
摘要Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (3-7), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (-)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells.
关键词Belamcanda Chinensis Belamcanosides a And b Gc Analysis Hmgcr Sqle Ldlr Sort1
DOI10.3390/molecules23030580
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61243
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China
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Song, Ying-Ying,Liu, Ying,Yan, Yong-Ming,et al. Phenolic Compounds from Belamcanda chinensis Seeds[J]. MOLECULES,2018,23(3):580.
APA Song, Ying-Ying,Liu, Ying,Yan, Yong-Ming,Lu, Xi-Feng,&Cheng, Yong-Xian.(2018).Phenolic Compounds from Belamcanda chinensis Seeds.MOLECULES,23(3),580.
MLA Song, Ying-Ying,et al."Phenolic Compounds from Belamcanda chinensis Seeds".MOLECULES 23.3(2018):580.
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