| Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica | |
Liu, Jie1,2 ; Zhou, Lutan1,3; He, Zhicheng1,3; Gao, Na1; Shang, Feineng1; Xu, Jianping1; Li, Zi1; Yang, Zengming2,4; Wu, Mingyi1; Zhao, Jinhua1
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| 2018-02-01 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 卷号 | 181页码:433-441 |
| 摘要 | Edible snails have been widely used as a health food and medicine in many countries. A unique glycosaminoglycan (AF-GAG) was purified from Achatina fulica. Its structure was analyzed and characterized by chemical and instrumental methods, such as Fourier transform infrared spectroscopy, analysis of monosaccharide composition, and 1D/2D nuclear magnetic resonance spectroscopy. Chemical composition analysis indicated that AF-GAG is composed of iduronic acid (IdoA) and N-acetyl-glucosamine (GlcNAc) and its average molecular weight is 118 kDa. Structural analysis clarified that the uronic acid unit in glycosaminoglycan (GAG) is the fully epimerized and the sequence of AF-GAG is -> 4)-alpha-GlcNAc (1 -> 4)-alpha-IdoA2S (1 ->. Although its structure with a uniform repeating disaccharide is similar to those of heparin and heparan sulfate, this GAG is structurally highly regular and homogeneous. Anticoagulant activity assays indicated that AF-GAG exhibits no anticoagulant activities, but considering its structural characteristic, other bioactivities such as heparanase inhibition may be worthy of further study. |
| 关键词 | Snail Glycosaminoglycan Chemical Structure Heparin Anticoagulant |
| DOI | 10.1016/j.carbpol.2017.10.091 |
| 语种 | 英语 |
| WOS记录号 | WOS:000418661000052 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/60604 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ TCM, Sch Pharm, Kunming 650500, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Inst Mat Med, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jie,Zhou, Lutan,He, Zhicheng,et al. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica[J]. CARBOHYDRATE POLYMERS,2018,181:433-441. |
| APA | Liu, Jie.,Zhou, Lutan.,He, Zhicheng.,Gao, Na.,Shang, Feineng.,...&Zhao, Jinhua.(2018).Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica.CARBOHYDRATE POLYMERS,181,433-441. |
| MLA | Liu, Jie,et al."Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica".CARBOHYDRATE POLYMERS 181(2018):433-441. |
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| liu2017.pdf（2955KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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