Induced High-Yield Production of Zeaxanthin, Lutein, and beta-Carotene by a Mutant of Chlorella zofingiensis
Huang, Weiping; Lin, Yan; He, Mingxia; Gong, Yuhao; Huang, Junchao
2018-01-31
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume66Issue:4Pages:891-897
AbstractNatural resources of zeaxanthin are extremely limited. A Chlorella zofingiensis mutant (CZ-bkt1), which could accumulate high amounts of zeaxanthin, was generated and characterized. CZ-bkt1 was achieved by treating the algal cells with a chemical mutagen followed by a color-based colony-screening approach. CZ-bkt1 was found to consist of a dysfunctional carotenoid ketolase, leading to the accumulation of zeaxanthin rather than to its downstream ketocarotenoid astaxanthin. Light irradiation, glucose, NaCl, and nitrogen deficiency all induced CZ-bkt1 to accumulate zeaxanthin. CZ-bkt1 accumulated zeaxanthin up to 7.00 +/- 0.82 mg/g when induced by high-light irradiation and nitrogen deficiency and up to 36.79 +/- 2.23 mg/L by additional feeding with glucose. Furthermore, in addition to zeaxanthin, CZ-bkt1 also accumulated high amounts of beta-carotene (7.18 +/- 0.72 mg/g or 34.64 +/- 1.39 mg/L) and lutein (13.81 +/- 1.23 mg/g or 33.97 +/- 2.61 mg/L). CZ-bkt1 is the sole species up to date with the ability to accumulate high amounts of the three carotenoids that are essential for human health.
KeywordCarotenoid Chlorella Zofingiensis Zeaxanthin Lutein Microalgae
DOI10.1021/acs.jafc.7b05400
Language英语
WOS IDWOS:000424313300017
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60565
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, Kunming Inst Bot, Dept Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Huang, Weiping,Lin, Yan,He, Mingxia,et al. Induced High-Yield Production of Zeaxanthin, Lutein, and beta-Carotene by a Mutant of Chlorella zofingiensis[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(4):891-897.
APA Huang, Weiping,Lin, Yan,He, Mingxia,Gong, Yuhao,&Huang, Junchao.(2018).Induced High-Yield Production of Zeaxanthin, Lutein, and beta-Carotene by a Mutant of Chlorella zofingiensis.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(4),891-897.
MLA Huang, Weiping,et al."Induced High-Yield Production of Zeaxanthin, Lutein, and beta-Carotene by a Mutant of Chlorella zofingiensis".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.4(2018):891-897.
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