Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.

doi:10.1016/j.fitote.2017.11.020

	Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.
	Yao, Jian-Neng 1,3; Chen, Lin 2; Chen, He-Ping 2; Zhao, Zhen-Zhu 1,3; Zhang, Shuai-Bing 1,3; Huang, Ying 1,3; Tang, Yang 1,3; Isaka, Masahiko 4; Li, Zheng-Hui 2; Feng, Tao 2; Liu, Ji-Kai 2
	2018-03-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	125 页码:227-234
摘要	Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Sterewn sp. Compounds 3 and 4 are structurally characterized as intact lanostanetype triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is a 24methylene-lanostane. The structures of these new compounds were established based on detailed 1D and 2D NMR spectroscopic analyses, along with quantum chemical NMR calculations. All isolates were evaluated for their in vitro cytotoxicities against five human tumor cell lines (including HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines). Compound 4 showed moderate cytotoxic activities against tumor cell lines SMMC-7721 and SW480 with IC50 values of 9.1 and 9.8 mu M, respectively.
关键词	Stereum Sp. Lanostane Triterpenoid Nmr Calculation Cytotoxicity
DOI	10.1016/j.fitote.2017.11.020
语种	英语
WOS记录号	WOS:000425560500034
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60552
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
推荐引用方式 GB/T 7714	Yao, Jian-Neng,Chen, Lin,Chen, He-Ping,et al. Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.[J]. FITOTERAPIA,2018,125:227-234.
APA	Yao, Jian-Neng.,Chen, Lin.,Chen, He-Ping.,Zhao, Zhen-Zhu.,Zhang, Shuai-Bing.,...&Liu, Ji-Kai.(2018).Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp..FITOTERAPIA,125,227-234.
MLA	Yao, Jian-Neng,et al."Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.".FITOTERAPIA 125(2018):227-234.