Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.
Yao, Jian-Neng1,3; Chen, Lin2; Chen, He-Ping2; Zhao, Zhen-Zhu1,3; Zhang, Shuai-Bing1,3; Huang, Ying1,3; Tang, Yang1,3; Isaka, Masahiko4; Li, Zheng-Hui2; Feng, Tao2; Liu, Ji-Kai2
2018-03-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume125Pages:227-234
AbstractTen new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Sterewn sp. Compounds 3 and 4 are structurally characterized as intact lanostanetype triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is a 24methylene-lanostane. The structures of these new compounds were established based on detailed 1D and 2D NMR spectroscopic analyses, along with quantum chemical NMR calculations. All isolates were evaluated for their in vitro cytotoxicities against five human tumor cell lines (including HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines). Compound 4 showed moderate cytotoxic activities against tumor cell lines SMMC-7721 and SW480 with IC50 values of 9.1 and 9.8 mu M, respectively.
KeywordStereum Sp. Lanostane Triterpenoid Nmr Calculation Cytotoxicity
DOI10.1016/j.fitote.2017.11.020
Language英语
WOS IDWOS:000425560500034
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60552
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
Recommended Citation
GB/T 7714
Yao, Jian-Neng,Chen, Lin,Chen, He-Ping,et al. Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.[J]. FITOTERAPIA,2018,125:227-234.
APA Yao, Jian-Neng.,Chen, Lin.,Chen, He-Ping.,Zhao, Zhen-Zhu.,Zhang, Shuai-Bing.,...&Liu, Ji-Kai.(2018).Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp..FITOTERAPIA,125,227-234.
MLA Yao, Jian-Neng,et al."Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp.".FITOTERAPIA 125(2018):227-234.
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