Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus

doi:10.1016/j.fitote.2018.01.003

	Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus
	Luo, Yong 1,3; Li, Xiao-Zhen 1,5; Xiang, Bin 1; Luo, Qi1 ; Liu, Jia-Wang 1,6; Yan, Yong-Ming 1,6; Sun, Qin 3,4; Cheng, Yong-Xian 1,2,6
	2018-03-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	125 页码:135-140
摘要	Three new diterpenoids, spicatusenes A-C (1-3), and eleven known ones (4-14) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were identified by spectroscopic methods. The cytotoxic activities of all the compounds against human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) were examined and found that compounds 2, 3, 6, 8, 10, and 13 were active against one or more cancer cell lines. Besides, the renoprotective effects of all the isolates in TGF-beta 1-induced rat kidney fibroblasts revealed that compounds 3-7, 9, 13, and 14 were beneficial for renal fibrosis. Finally, a plausible biosynthetic pathway for 1 via a Hantzsch-type reaction was proposed.
关键词	Clerodendranthus Spicatus Diterpenoids Alkaloid Cytotoxic Activities Renal Fibrosis
DOI	10.1016/j.fitote.2018.01.003
语种	英语
WOS记录号	WOS:000425560500022
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60551
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China 3.Southwest Med Univ, Chinese Med Hosp, Dept Pharmaceut Preparat, Luzhou 646000, Peoples R China 4.Southwest Med Univ, Luzhou 646000, Peoples R China 5.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 6.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Sch Med,Guangdong Key Lab Genome Stabil & Dis Pre, Shenzhen 518060, Peoples R China
推荐引用方式 GB/T 7714	Luo, Yong,Li, Xiao-Zhen,Xiang, Bin,et al. Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus[J]. FITOTERAPIA,2018,125:135-140.
APA	Luo, Yong.,Li, Xiao-Zhen.,Xiang, Bin.,Luo, Qi.,Liu, Jia-Wang.,...&Cheng, Yong-Xian.(2018).Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus.FITOTERAPIA,125,135-140.
MLA	Luo, Yong,et al."Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus".FITOTERAPIA 125(2018):135-140.