Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation
Liu, Jia-Wang1,4; Zhang, Min-Yu2; Yan, Yong-Min2; Wei, Xiao-Yi5; Dong, Lu1; Zhu, Yan-Xia2; Cheng, Yong-Xian1,2,3
2018-03-02
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume83Issue:5Pages:2725-2733
AbstractThe new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures were assigned by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, and 3 is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6 hexacyclic framework, while 4 possesses a 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 are proposed. Biochemical studies show that compound 1 promotes ca. 60% expression of keratinocyte-specific markers in adipose derived stem cells at 10 mu M.
DOI10.1021/acs.joc.7b03182
Language英语
WOS IDWOS:000426803300022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60528
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci,Hlth Sci Ctr, Shenzhen Key Lab Antiaging & Regenerat Med,Dept C, Shenzhen 518060, Peoples R China
3.Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jia-Wang,Zhang, Min-Yu,Yan, Yong-Min,et al. Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(5):2725-2733.
APA Liu, Jia-Wang.,Zhang, Min-Yu.,Yan, Yong-Min.,Wei, Xiao-Yi.,Dong, Lu.,...&Cheng, Yong-Xian.(2018).Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation.JOURNAL OF ORGANIC CHEMISTRY,83(5),2725-2733.
MLA Liu, Jia-Wang,et al."Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation".JOURNAL OF ORGANIC CHEMISTRY 83.5(2018):2725-2733.
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