中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Effects of indole alkaloids from leaf of &ITAlstonia scholaris&IT on post-infectious cough in mice
作者: Zhao, Yun-Li1; Yang, Zi-Feng2; Shang, Jian-Hua1; Huang, Wan-Yi2; Wang, Bei1; Wei, Xin1; Khan, Afsar1, 3; Yuan, Zhi-Wei4; Liu, Ya-Ping1; Wang, Yi-Fen1; Wang, Xin-Hua2; Luo, Xiao-Dong1, 2
刊名: JOURNAL OF ETHNOPHARMACOLOGY
关键词: Leaf of Alstonia scholaris ; Indole alkaloids ; Scholaricine ; 19-Epischolaricine ; Vallesamine ; Picrinine ; Post-infectious cough
英文摘要: Ethnopharmacological relevance: Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people.& para;& para;Aim of the study: To provide experimental data of clinical adaption of total indole alkaloids (TA) from leaf of A. scholaris for treating post-infectious cough in phase II clinical trial.& para;& para;Materials and methods: To model post-infectious cough, all animals except control group were instilled intra-tracheal with lipopolysaccharide (LPS) (80 mu g/50 mu L/mouse), followed by subsequent exposure to cigarette smoke (CS) for 30 min per day for a total of 30 days. Mice were orally given TA at dose of 10, 25, 50 mg/kg, and four main alkaloids (Sch: scholaricine, Epi: 19-epischolaricine, Val: vallesamine, Pic: picrinine) once daily. Cellular infiltration was assessed in the broncho-alveolar lavage fluid (BALF). Expression of interleukin-6 (IL-6) and C-reactive protein (CRP) in the serum was determined, the superoxide dismutase (SOD) activity as well as malondialdehyde (MDA) content in the serum and homogenate were examined. Finally, histopathological examination in the lungs was assessed by H. E. staining.& para;& para;Results: After administration of TA and four major alkaloids respectively, the symptoms of cough in mice were obviously attenuated. Total white blood cells (WBC) and neutrophils (NEU) amounts in BALF were reduced obviously and the pathological damage of lung was also attenuated. There was also significant reduction in IL-6, CRP, MDA and a marked improvement in SOD.& para;& para;Conclusions: The efficacy of indole alkaloids against post-infectious cough (PIC) was shown in the down-regulation of inflammatory cells, cytokines, and the balance of antioxidants. What's more, the pharmacological effects of TA were better than single indole alkaloid, which might be related to the synergic effect of four major alkaloids.
出版日期: 2018-05-23
卷号: 218, 页码:69-75
DOI标识: 10.1016/j.jep.2018.02.040
语种: 英语
ISSN号: 0378-8741
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/60493
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China
3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
4.Kunming Med Univ, Hosp 2, Kunming 650101, Yunnan, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Yun-Li]'s Articles
[Yang, Zi-Feng]'s Articles
[Shang, Jian-Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Yun-Li]‘s Articles
[Yang, Zi-Feng]‘s Articles
[Shang, Jian-Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院昆明植物研究所 - Feedback
Powered by CSpace