Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT
Wang, Yue-Hu1,2,5; Shi, Min3,4; Niu, Hong-Mei1,2; Yang, Jun1,2,5; Xia, Meng-Yuan1,2,5; Luo, Ji-Feng1,2,5; Chen, Ying-Jie6; Zhou, Yi-Ping3,4; Li, Heng1,2
2018-05-23
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
卷号218页码:45-50
摘要Ethnopharmacological relevance: Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian oral liquid, and Qi-Zhen capsules. P. forrestii, a substitute for Chong-lou, is planted at a large scale in the Yunnan Province of China.& para;& para;Aim of the study: To clarify the active chemical constituents of P. forrestii and evaluate the in vitro and in vivo anticancer activities of the total saponins from P. forrestii.& para;& para;Materials and methods: The total saponins of P. forrestii were extracted and separated to yield pure compounds by chromatographic techniques, and the structures of the isolates were elucidated by spectroscopic methods. The cytotoxicity of the crude extracts, total saponins, and chemical constituents were evaluated using an MTS assay. In vivo antitumor activities of the total saponins from P. forrestii were measured using H22 tumor-bearing mice by intraperitoneal (ip) administration.& para;& para;Results: Eight compounds, including polyphyllin D (1), formosanin C (2), dioscin (3), diosgenin-3-O-alpha-L--rhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranoside (4), paris saponin H (5), pennogenin-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glucopyranoside (6), pariposide A (7), and crustecdysone (8), were isolated from the total saponins of P. forrestii. The total saponins and compounds 1-6 showed significant inhibitory activity against the growth of the HL-60, SMMC-7721, A 549, MCF-7, and SW480 cell lines. The total saponins from P. forrestii had a tumor-inhibitory effect in H22 tumor-bearing mice upon ip (2.25 mg/kg dose) administration, with an inhibition rate of 42.6% compared with cisplatin (ip, 2 mg/kg dose, 53.9% inhibition rate). & para;& para;Conclusion: The results support that P. forrestii could be a substitute for P. polyphylla var. yunnanensis as an anticancer medicine.
关键词Melanthiaceae Paris Forrestii Saponins Cytotoxicity Anticancer
DOI10.1016/j.jep.2018.02.022
语种英语
WOS记录号WOS:000430028100005
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60492
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
5.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
6.Kunming Med Univ, Sch Basic Med Sci, Kunming 650500, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yue-Hu,Shi, Min,Niu, Hong-Mei,et al. Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT[J]. JOURNAL OF ETHNOPHARMACOLOGY,2018,218:45-50.
APA Wang, Yue-Hu.,Shi, Min.,Niu, Hong-Mei.,Yang, Jun.,Xia, Meng-Yuan.,...&Li, Heng.(2018).Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT.JOURNAL OF ETHNOPHARMACOLOGY,218,45-50.
MLA Wang, Yue-Hu,et al."Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT".JOURNAL OF ETHNOPHARMACOLOGY 218(2018):45-50.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
wang2018.pdf(723KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yue-Hu]的文章
[Shi, Min]的文章
[Niu, Hong-Mei]的文章
百度学术
百度学术中相似的文章
[Wang, Yue-Hu]的文章
[Shi, Min]的文章
[Niu, Hong-Mei]的文章
必应学术
必应学术中相似的文章
[Wang, Yue-Hu]的文章
[Shi, Min]的文章
[Niu, Hong-Mei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。