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Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT
Wang, Yue-Hu1,2,5; Shi, Min3,4; Niu, Hong-Mei1,2; Yang, Jun1,2,5; Xia, Meng-Yuan1,2,5; Luo, Ji-Feng1,2,5; Chen, Ying-Jie6; Zhou, Yi-Ping3,4; Li, Heng1,2
2018-05-23
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume218Issue:1Pages:45-50
Abstract

Ethnopharmacological relevance: Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian oral liquid, and Qi-Zhen capsules. P. forrestii, a substitute for Chong-lou, is planted at a large scale in the Yunnan Province of China.& para;& para;Aim of the study: To clarify the active chemical constituents of P. forrestii and evaluate the in vitro and in vivo anticancer activities of the total saponins from P. forrestii.& para;& para;Materials and methods: The total saponins of P. forrestii were extracted and separated to yield pure compounds by chromatographic techniques, and the structures of the isolates were elucidated by spectroscopic methods. The cytotoxicity of the crude extracts, total saponins, and chemical constituents were evaluated using an MTS assay. In vivo antitumor activities of the total saponins from P. forrestii were measured using H22 tumor-bearing mice by intraperitoneal (ip) administration.& para;& para;Results: Eight compounds, including polyphyllin D (1), formosanin C (2), dioscin (3), diosgenin-3-O-alpha-L--rhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranoside (4), paris saponin H (5), pennogenin-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glucopyranoside (6), pariposide A (7), and crustecdysone (8), were isolated from the total saponins of P. forrestii. The total saponins and compounds 1-6 showed significant inhibitory activity against the growth of the HL-60, SMMC-7721, A 549, MCF-7, and SW480 cell lines. The total saponins from P. forrestii had a tumor-inhibitory effect in H22 tumor-bearing mice upon ip (2.25 mg/kg dose) administration, with an inhibition rate of 42.6% compared with cisplatin (ip, 2 mg/kg dose, 53.9% inhibition rate). & para;& para;Conclusion: The results support that P. forrestii could be a substitute for P. polyphylla var. yunnanensis as an anticancer medicine.

KeywordMelanthiaceae Paris Forrestii Saponins Cytotoxicity Anticancer
DOI10.1016/j.jep.2018.02.022
Language英语
WOS IDWOS:000430028100005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60492
Collection资源植物与生物技术所级重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
5.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
6.Kunming Med Univ, Sch Basic Med Sci, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yue-Hu,Shi, Min,Niu, Hong-Mei,et al. Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT[J]. JOURNAL OF ETHNOPHARMACOLOGY,2018,218(1):45-50.
APA Wang, Yue-Hu.,Shi, Min.,Niu, Hong-Mei.,Yang, Jun.,Xia, Meng-Yuan.,...&Li, Heng.(2018).Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT.JOURNAL OF ETHNOPHARMACOLOGY,218(1),45-50.
MLA Wang, Yue-Hu,et al."Substituting one &ITParis &ITfor another?&IT In vitro&IT cytotoxic and &ITin vivo &ITantitumor activities of &ITParis forrestii&IT, a substitute of &ITParis polyphylla &ITvar. &ITyunnanensis&IT".JOURNAL OF ETHNOPHARMACOLOGY 218.1(2018):45-50.
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