KIB OpenIR  > 昆明植物所硕博研究生毕业学位论文
Alternative TitleFurther Study On Glycoside from Panax notoginseng (Burk.) F.H.Chen
Thesis Advisor杨崇仁
Degree Grantor中国科学院昆明植物研究所
Place of Conferral中国科学院昆明植物研究所
Keyword三七 三七叶 三七根腐病 五加科 三七皂甙 人参皂甙
Other AbstractThe thesis consists of three parts. The first part is the further studies on the glycosides of the roots and leaves of P. notoginseng. The second part is the study on the chemical ecology of P. notoginseng root rot. The third part reviews the advances in the chemistry and pharmacology of P. notoginseng in the latest decade. Panax notoginseng (Burk.) F.H.Chen ex C.Y.Wu et K.M.Feng, also called "San-Qi", "Tian-Qi", "Sanqi ginseng" or "Jin-Bu-Huan" locally, belongs to Araliaceae. It is indigenous to Yunnan province, and called "South Ginseng". According to the chemical and pharmacological studies, its triterpenoids are considered as the active components of Panax genus. The triterpenoids are abundant in notoginseng, which has the highest content of those components in Panax genus. Especially, the contents of ginsenoside Rg, and Rb, of P. notoginseng are higher than those of P. ginseng' and P. quinquefolium, which are well-known medicinal plants. So far, forty-four saponins have been isolated from P. notoginseng. It has found its total saponins and some of them have activities in hematology, cardiovascular system, cerebrovascular system, neural system, immunity system, substance metabolism, and anti-inflammation, prolong life, anticancer activities. In the further study on the total saponins of the roots of P. notoginseng, thirteen saponins were isolated and identified. One of them is a new compound, which is named notoginsenoside RiO(l). The others are ginsenoside Rh,(2), Rg3(4), Rg2(6), Rgl(8), Rd(10), Re(ll), Rb,(13), Rb2(14), 20(R)-ginsenoside Rg3(5), notoginsenoside R2(7), R,(12), and gypenoside XVII(9). The leaves of P. notoginseng is a natural medicine too. Eighteen compounds were isolated from the ethanol extract of the leaves, and fifteen compounds were identified by spectroscopic analysis. Thirteen of them are saponins: ginsenoside Rh2(l), F2(4), Rg3(5), Rg,(7), Rd(8), Re(ll), Rb3(13), Rb,(14), Rc(15), gypenoside XIII(2), IX(9), XVII(IO), notogenoside R,(12), and two of them are flavanone: liquirtigenin(3), liquiritin apioside (6). Amoung the mentioned comounds, 1,2,3,6 are first reported of this species. In the leaves of P. notoginseng, most of glycosides are the protopanaxdiol type saponins, only a few of them are the protopanaxtriol type saponins (as ginsenoside Rg,, Re, notoginsenoside R,) and flavanones. P. notoginseng root rot, which is called "Ji-Shi-Lan" or "Chou-Qi" locally, is a destructive disease, which made 5-20% of the plant loss annually. Isolated from root rot of P. notoginseng, 90% of the pathogenic bacteria is Pseudomones spp., along with fewer fungi such as Fusarhtm spp.. Sixteen saponins were isolated and identified from the fresh roots of P. notoginseng root rot. There are three new compounds, named notoginsenoside R, (6), ROO, R^W, and thirteen known compounds ginsenoside Rh,(l), Rg3(2), Rg2(3), Rg), Rd(10), Re(ll), Rb-2(14), Rb,(15), Rc(16), notoginsenoside R2(7), R,(12), R3(13), and gypenoside XVII(9). The saponins of P. notoginseng root rot are different from normal ones. The chain of some saponins were changed, but were not transformed by the pathogenic bacteria.
Document Type学位论文
Recommended Citation
GB/T 7714
李海舟. 三七皂甙的进一步化学研究[D]. 中国科学院昆明植物研究所. 中国科学院昆明植物研究所,2000.
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