三七皂甙的进一步化学研究
其他题名Further Study On Glycoside from Panax notoginseng (Burk.) F.H.Chen
李海舟
学位类型硕士
导师杨崇仁
2000
学位授予单位中国科学院昆明植物研究所
学位授予地点中国科学院昆明植物研究所
关键词三七 三七叶 三七根腐病 五加科 三七皂甙 人参皂甙
摘要该论文分为三个部分.第一部分论述对三七根、茎叶化学成分的进一步系统研究,第二部分报导三七病害的化学生态学研究工作;第三部分综述近年来(90-99年)三七在化学和药理学方面的研究进展.三七(Panaxnotoginseng(Burk,)F.H.ChenexC.Y.WuetK.M.Feng),又名田七、人参三七、田三七、山漆、金不换等,为五加科人参属植物,是云南的地道药材,有"南方人参"之称.现代化学和药理学研究认为三萜皂甙是人参属的主要生理活性成分,三七中含有丰富的这类化合物,是人参属植物中含量最高者,特别是人参皂甙Rg<,1>和Rb<,1>的含量比人参和西洋参高得多.迄今,已从三七全株中分离到44个三萜皂甙,发现三七总皂甙和部分单体皂甙在血液系统、心脑血管系统、神经系统、免疫系统、物质代谢以及抗炎、抗衰老、抗肿瘤等方面均有较好活性.
其他摘要The thesis consists of three parts. The first part is the further studies on the glycosides of the roots and leaves of P. notoginseng. The second part is the study on the chemical ecology of P. notoginseng root rot. The third part reviews the advances in the chemistry and pharmacology of P. notoginseng in the latest decade. Panax notoginseng (Burk.) F.H.Chen ex C.Y.Wu et K.M.Feng, also called "San-Qi", "Tian-Qi", "Sanqi ginseng" or "Jin-Bu-Huan" locally, belongs to Araliaceae. It is indigenous to Yunnan province, and called "South Ginseng". According to the chemical and pharmacological studies, its triterpenoids are considered as the active components of Panax genus. The triterpenoids are abundant in notoginseng, which has the highest content of those components in Panax genus. Especially, the contents of ginsenoside Rg, and Rb, of P. notoginseng are higher than those of P. ginseng' and P. quinquefolium, which are well-known medicinal plants. So far, forty-four saponins have been isolated from P. notoginseng. It has found its total saponins and some of them have activities in hematology, cardiovascular system, cerebrovascular system, neural system, immunity system, substance metabolism, and anti-inflammation, prolong life, anticancer activities. In the further study on the total saponins of the roots of P. notoginseng, thirteen saponins were isolated and identified. One of them is a new compound, which is named notoginsenoside RiO(l). The others are ginsenoside Rh,(2), Rg3(4), Rg2(6), Rgl(8), Rd(10), Re(ll), Rb,(13), Rb2(14), 20(R)-ginsenoside Rg3(5), notoginsenoside R2(7), R,(12), and gypenoside XVII(9). The leaves of P. notoginseng is a natural medicine too. Eighteen compounds were isolated from the ethanol extract of the leaves, and fifteen compounds were identified by spectroscopic analysis. Thirteen of them are saponins: ginsenoside Rh2(l), F2(4), Rg3(5), Rg,(7), Rd(8), Re(ll), Rb3(13), Rb,(14), Rc(15), gypenoside XIII(2), IX(9), XVII(IO), notogenoside R,(12), and two of them are flavanone: liquirtigenin(3), liquiritin apioside (6). Amoung the mentioned comounds, 1,2,3,6 are first reported of this species. In the leaves of P. notoginseng, most of glycosides are the protopanaxdiol type saponins, only a few of them are the protopanaxtriol type saponins (as ginsenoside Rg,, Re, notoginsenoside R,) and flavanones. P. notoginseng root rot, which is called "Ji-Shi-Lan" or "Chou-Qi" locally, is a destructive disease, which made 5-20% of the plant loss annually. Isolated from root rot of P. notoginseng, 90% of the pathogenic bacteria is Pseudomones spp., along with fewer fungi such as Fusarhtm spp.. Sixteen saponins were isolated and identified from the fresh roots of P. notoginseng root rot. There are three new compounds, named notoginsenoside R, (6), ROO, R^W, and thirteen known compounds ginsenoside Rh,(l), Rg3(2), Rg2(3), Rg), Rd(10), Re(ll), Rb-2(14), Rb,(15), Rc(16), notoginsenoside R2(7), R,(12), R3(13), and gypenoside XVII(9). The saponins of P. notoginseng root rot are different from normal ones. The chain of some saponins were changed, but were not transformed by the pathogenic bacteria.
页数105
语种中文
文献类型学位论文
条目标识符http://ir.kib.ac.cn/handle/151853/604
专题昆明植物所硕博研究生毕业学位论文
推荐引用方式
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李海舟. 三七皂甙的进一步化学研究[D]. 中国科学院昆明植物研究所. 中国科学院昆明植物研究所,2000.
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