五种药用植物和紫色粉胞牛肝菌的化学成分研究
其他题名Study on the chemical constituents of five medicinal plants and tylopilus plumbeoviolaceus
吴少华
学位类型博士
导师郝小江
2001
学位授予单位中国科学院昆明植物研究所
学位授予地点中国科学院昆明植物研究所
关键词芍药科 紫色粉孢牛肝菌 一支箭 单萜甙倍半萜甙 三萜
摘要该论文为硕博连读学位论文,共由五章组成,第一章和第五章为博士期间的研究内容,第二、三、四章为硕士期间的研究内容.第一章详细论述了芍药科(Paeoniaceae三种植物紫牡丹(PaeoniadelavayiFranch.)、川赤芍(PaeoniaveitchiiLynch.)和中药丹皮(PaeoniasuffruticosaAndr.)的化学成分研究,并简要地讨论了其化学成分对该科植物分类归属的意义.第二章介绍了对牛肝菌科(Boletaceae)粉胞牛肝菌属的一种大型真菌紫色粉孢牛肝菌(Tylopilusp1umbeoviolaceus)的化学成分研究.第三章介绍了对菊科(Compositae)还阳参属植物一支箭(Crepisnapifera)的化学成分研究.第四章介绍了对叨里木科(Toricelliaceae)鞘柄木属植物大接骨丹(Toricelliaangulata)的化学成分研究.从上述六种植物中共鉴定了83个化合物,其中有20个为新化合物.已鉴定的化合物类型涉及单萜、单萜甙、倍半萜甙、三萜及其甙、麦角甾醇、黄酮、黄酮甙、核苷、苯丙素甙以及苯环取代物等.第五章为综述,包括两部分内容,第一部分综述了芍药科(Paeoniaceae)植物的化学成分及其生理活性:第二部分总结了麦角甾烷及胆甾烷B环裂解和转化的两种途径.
其他摘要The thesis mainly contains five chapters, in which the chemical constituents of six plants, Paeonia delavayi Franch., Paeonia veitchii Lynch, and Paeonia suffruticosa Andr., Tylopilus plumbeoviolaceus, Crepis napifera, Toricellia angulata have been researched. Eighty-three compounds were isolated and identified, including twenty new compounds. These compounds covered monoterpenes, monoterpene glycosides, sesquiterpene glycosides, triterpenoids and glycosides, ergosterols, flavanones and glycosides, nucleosides, phenylpropanoid glycosides and aromatic derivatives. 1. Chemical Constituents from Three Paeonia Plants The root cortex of the genus Paeonia plants is an important crude drug used in Chinese traditional medicine as an analgesic, sedative and anti-inflammatory agent. It is also frequently used as a remedy for cardiovarscular, hypertension, extravasated blood, stagnated blood, and female diseases in traditional oriental medicine. This chapter detailed the chemical constituents of Paeonia delavayi Franch., Paeonia veitchii Lynch, and Paeonia suffruticosa Andr., respectively. Thirty-two compounds were isolated from the root cortex of Paeonia delavayi, mainly including monoterpenes and glycosides, triterpenoids and benzoyl derivatives. They were 9-hydroxy-paeonilactone-A (1), 4-O-ethyl-paeoniflorin (2), paeoniflorin (3), oxypaeoniflorin (4), benzoylpaeoniflorin (5), benzoyloxypaeoniflorin (6),' 6'-0-benzoyl-4"-hydroxy-3"-methoxy-paeoniflorin (7), 4-<9-methyl-4"-hydroxy-3 "-methoxy-paeoniflorin (8), albiflorin (9), paeonivayin 1 (10), 6'-Obenzoylalbiflorin (11), paeoniflorigenone (12), paeonisuffral (13a, 13b), paeonilide (14), paeoninside (15), palbinone (16), 3/?, Afi, 23-trihydroxy-24, 30-dinorolean-12, 20 (29)-dien-28-oic acid (17) bederagenin (18), aijunglucoside II (19), daucosterol (20), 3, 7-dimethoxy quercitrin (21), astragalin" (22), methyl gallate (23), 3-methoxy-4-hydroxy methyl-benzoate (24), 3, 5-dimethoxy-4-hydroxy methylbenzoate (25), syringic acid (26), vanillic acid (27), benzoic acid (28), ohydroxy benzoic acid (-29), p-hydtoxy benzoic acid (30), palmitic acid-2, 3-dihydroxy-propanenyl ester (31), 2-hydroxy-l-linoleic acid-3-palmitic acid-propanenyl ester (32). Among them, compounds 1,2, 7, 8,11,15,17 are new. Thirteen compounds were obtained from the Chinese traditional medicine P. veitchii, including monoterpenoids, nortriterpenoids and aromatic derivatives. They were acetoxypaeoniflorin (1), paeoniveitone (2), akebonic acid (3), 3^-hydroxy-24, 30-dinorolean-4 (23), 12, 20 (29)-trien-28-oic acid (paeonenolide A, 4), 3# 4y3-dihydroxy-24, 30-dinorolean-12, 20 (29)-dien-28-oic acid (paeonenolide B, 5), paeonenolide C (6), lla, 12a-epoxy-3p, 4p, 23-trihydroxy-24, 30-dinorolean-20 (29)-en-28, 13p-olide (paeonenolide D, 7), paeonenolide E (8), paeonenolide F (9), paeonenolide G (10), bis (2-hydroxy-benzyl) ether (11), 2-hydroxy-4, 5-dimethyl-benzoic acid (12), 2-hydroxy-benzyl alcohol (13). Among them, compound 1 is a new monoterpene glycoside, compound 2 is a new monoterpenoid, and compounds 4-10 are seven new nortriterpenoids. Nine compounds were isolated from the Chinese medicine P. suffruticosa (Mudanpi). They were determined as betulinic acid (1), betulin (2), oleanolic acid (3), 3
页数190
语种中文
文献类型学位论文
条目标识符http://ir.kib.ac.cn/handle/151853/576
专题昆明植物所硕博研究生毕业学位论文
推荐引用方式
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吴少华. 五种药用植物和紫色粉胞牛肝菌的化学成分研究[D]. 中国科学院昆明植物研究所. 中国科学院昆明植物研究所,2001.
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