Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine

doi:10.3390/molecules14010089

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	Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine
	Nimgirawath, Surachai 1; Lorpitthaya, Rujee 1; Wanbanjob, Asawin 1; Taechowisan, Thongchai 2; Shen, Yue-Mao 3
通讯作者	surachai@su.ac.th ; G050010@ntu.edu.sg ; winsusc@gmail.com ; tthongch@su.ac ; yshen@mail.kib.ac.cn
	2009
发表期刊	MOLECULES
ISSN	1420-3049
卷号	14 期号:1 页码:89-101
摘要	The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine inhibits the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
关键词	Alkaloid Anti-inflammatory Activity Aporphine Isoquinoline Synthesis Radical Cyclization
学科领域	Chemistry, Organic
DOI	10.3390/molecules14010089
收录类别	SCI
语种	英语
WOS记录号	WOS:000262791200009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5591
专题	离退休
作者单位	1.Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand 2.Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,et al. Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine[J]. MOLECULES,2009,14(1):89-101.
APA	Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,Taechowisan, Thongchai,&Shen, Yue-Mao.(2009).Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine.MOLECULES,14(1),89-101.
MLA	Nimgirawath, Surachai,et al."Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine".MOLECULES 14.1(2009):89-101.

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