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Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine
Nimgirawath, Surachai1; Lorpitthaya, Rujee1; Wanbanjob, Asawin1; Taechowisan, Thongchai2; Shen, Yue-Mao3
Corresponding Authorsurachai@su.ac.th ; G050010@ntu.edu.sg ; winsusc@gmail.com ; tthongch@su.ac ; yshen@mail.kib.ac.cn
2009
Source PublicationMOLECULES
ISSN1420-3049
Volume14Issue:1Pages:89-101
AbstractThe structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine inhibits the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
KeywordAlkaloid Anti-inflammatory Activity Aporphine Isoquinoline Synthesis Radical Cyclization
Subject AreaChemistry, Organic
DOI10.3390/molecules14010089
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000262791200009
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5591
Collection离退休
Affiliation1.Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand
2.Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,et al. Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine[J]. MOLECULES,2009,14(1):89-101.
APA Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,Taechowisan, Thongchai,&Shen, Yue-Mao.(2009).Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine.MOLECULES,14(1),89-101.
MLA Nimgirawath, Surachai,et al."Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine".MOLECULES 14.1(2009):89-101.
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