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Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine
Nimgirawath, Surachai1; Lorpitthaya, Rujee1; Wanbanjob, Asawin1; Taechowisan, Thongchai2; Shen, Yue-Mao3
2009
发表期刊MOLECULES
ISSN1420-3049
卷号14期号:1页码:89-101
摘要The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine inhibits the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
关键词Alkaloid Anti-inflammatory Activity Aporphine Isoquinoline Synthesis Radical Cyclization
学科领域Chemistry, Organic
DOI10.3390/molecules14010089
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000262791200009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5591
专题离退休
作者单位1.Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand
2.Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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GB/T 7714
Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,et al. Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine[J]. MOLECULES,2009,14(1):89-101.
APA Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,Taechowisan, Thongchai,&Shen, Yue-Mao.(2009).Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine.MOLECULES,14(1),89-101.
MLA Nimgirawath, Surachai,et al."Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine".MOLECULES 14.1(2009):89-101.
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