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题名: Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine
作者: Nimgirawath, Surachai1; Lorpitthaya, Rujee1; Wanbanjob, Asawin1; Taechowisan, Thongchai2; Shen, Yue-Mao3
刊名: MOLECULES
关键词: Alkaloid ; Anti-inflammatory Activity ; Aporphine ; Isoquinoline ; Synthesis ; Radical Cyclization
英文摘要: The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine inhibits the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
出版日期: 2009
卷号: 14, 期号:1, 页码:89-101
DOI标识: 10.3390/molecules14010089
语种: 英语
收录类别: SCI
学科分类: Chemistry, Organic
ISSN号: 1420-3049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5591
Appears in Collections:离退休_期刊论文

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作者单位: 1.Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand
2.Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Nimgirawath, S; Lorpitthaya, R; Wanbanjob, A; Taechowisan, T; Shen, YM.Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine,MOLECULES,2009,14(1):89-101
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