New cytotoxic steroid from Stachyurus himalaicus var. himalaicus

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	New cytotoxic steroid from Stachyurus himalaicus var. himalaicus
	Wang, Yun-Song ; Yang, Jing-Hua ; Luo, Shi-De ; Zhang, Hong-Bin ; Li, Liang
通讯作者	wangys99@hotmail.com ; yangjh@ynu.edu.cn ; shideluo@hotmail.com ; zhanghb@ynu.edu.cn ; liliang5758@hotmail.com
	2007-03-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	12 期号:3 页码:536-542
摘要	A phytochemical study of the ethanolic extract of Stachyurus himalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 mu g/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
关键词	Steroids Stachyurus Himalaicus Var. Himalaicus Stachyuraceae Cytotoxity
学科领域	Chemistry, Organic
收录类别	SCI
语种	英语
WOS记录号	WOS:000245437400023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5589
专题	离退休
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,et al. New cytotoxic steroid from Stachyurus himalaicus var. himalaicus[J]. MOLECULES,2007,12(3):536-542.
APA	Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,Zhang, Hong-Bin,&Li, Liang.(2007).New cytotoxic steroid from Stachyurus himalaicus var. himalaicus.MOLECULES,12(3),536-542.
MLA	Wang, Yun-Song,et al."New cytotoxic steroid from Stachyurus himalaicus var. himalaicus".MOLECULES 12.3(2007):536-542.

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