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New cytotoxic steroid from Stachyurus himalaicus var. himalaicus
Wang, Yun-Song; Yang, Jing-Hua; Luo, Shi-De; Zhang, Hong-Bin; Li, Liang
2007-03-01
发表期刊MOLECULES
ISSN1420-3049
卷号12期号:3页码:536-542
摘要A phytochemical study of the ethanolic extract of Stachyurus himalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 mu g/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
关键词Steroids Stachyurus Himalaicus Var. Himalaicus Stachyuraceae Cytotoxity
学科领域Chemistry, Organic
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000245437400023
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5589
专题离退休
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,et al. New cytotoxic steroid from Stachyurus himalaicus var. himalaicus[J]. MOLECULES,2007,12(3):536-542.
APA Wang, Yun-Song,Yang, Jing-Hua,Luo, Shi-De,Zhang, Hong-Bin,&Li, Liang.(2007).New cytotoxic steroid from Stachyurus himalaicus var. himalaicus.MOLECULES,12(3),536-542.
MLA Wang, Yun-Song,et al."New cytotoxic steroid from Stachyurus himalaicus var. himalaicus".MOLECULES 12.3(2007):536-542.
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