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题名: New cytotoxic steroid from Stachyurus himalaicus var. himalaicus
作者: Wang, Yun-Song; Yang, Jing-Hua; Luo, Shi-De; Zhang, Hong-Bin; Li, Liang
刊名: MOLECULES
关键词: steroids ; Stachyurus himalaicus var. himalaicus ; Stachyuraceae ; cytotoxity
英文摘要: A phytochemical study of the ethanolic extract of Stachyurus himalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 mu g/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.
出版日期: 2007-03-01
卷号: 12, 期号:3, 页码:536-542
语种: 英语
收录类别: SCI
学科分类: Chemistry, Organic
ISSN号: 1420-3049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5589
Appears in Collections:离退休_期刊论文

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作者单位: 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Wang, YS; Yang, JH; Luo, SD; Zhang, HB; Li, L.New cytotoxic steroid from Stachyurus himalaicus var. himalaicus,MOLECULES,2007,12(3):536-542
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