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题名: Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae
作者: Zhao, Zhen-Zhu1, 3; Chen, He-Ping1, 2; Huang, Ying1, 3; Zhang, Shuai-Bing1, 3; Li, Zheng-Hui2; Feng, Tao2; Liu, Ji-Kai2
刊名: PHYTOCHEMISTRY
关键词: Ascomycete ; Daldinia childiae ; Polyketide ; 8,14-Seco-ergosterol ; Anti-bacterial ; Anti-NO activity
英文摘要: Seven previously undescribed polyketides, namely childinins A-G, and one previously undescribed 8,14- (seco-ergosterol, namely childinasterone A, were obtained from the fruiting bodies of Daldinia childiae. Their structures and absolute configurations were established via extensive spectroscopic analyses, single-crystal X-ray diffraction, and TDDFT/ECD calculations. Childinins A represents the first example of natural product possessing a previously undescribed 6H-naphtho[2,1-c]chromen-6-one scaffold. The single crystal X-ray diffraction of childinasterone A unambiguously determined the absolute configuration of a 8,14-seco-ergosterol skeleton. Childinins A, B, F and G (MIC90 54.9 mu g.mL(-1)) showed antibacterial activities. Childinasterone A showed significant anti-NO activity (IC50 21.2 mu M) and weak activities against SMMC-7721, MCF-7 and SW480 cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
出版日期: 2017-10-01
卷号: 142, 页码:68-75
DOI标识: 10.1016/j.phytochem.2017.06.020
语种: 英语
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54876
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhao, Zhen-Zhu,Chen, He-Ping,Huang, Ying,et al. Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae[J]. PHYTOCHEMISTRY,2017,142:68-75.
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