| Anti-inflammatory and anti-tumour effects of Abies georgei extracts | |
| Yang, Xian-Wen1,2; Zeng, Hua-Wu1; Liu, Xiao-Hua1; Li, Su-Mei3; Xu, Wen; Shen, Yun-Heng1; Zhang, Chuan1; Zhang, Wei-Dong1 | |
| 2008-07-01 | |
| 发表期刊 | JOURNAL OF PHARMACY AND PHARMACOLOGY
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| 卷号 | 60期号:7页码:937-941 |
| 摘要 | Chloroform (AGC), ethyl acetate (AGE) and n-butanol (AGB) extracts of Abies georgei were investigated for anti-tumour and anti-inflammatory activities in-vitro and in-vivo. AGC exhibited potent antiproliferative effects against A549, LOVO, QGY-7703 and 6T-CEM tumour cells, with EC50 values of 77.5, 7.8, 11.1 and 32.8 mu gmL(-1), respectively. It also inhibited the growth of 5180 sarcoma implanted into mice; tumour growth inhibition ratios were 46.7, 53.1 and 31.0% of controls at doses of 100, 200 and 400 mg kg(-1), respectively. AGE showed significant anti-inflammatory activities in the carrageenin-induced acute pedal oedema model in rats and dimethylbenzene-induced ear oedema in mice at doses of 140 mg kg(-1) and 200 mgkg(-1) p.o., respectively. Primary mechanism studies in-vitro showed that AGE inhibited platelet aggregation induced in rabbits by arachidonic acid (AA), with an IC50 of 14.4 mu gmL(-1). Its effect on AA metabolism was also studied in mouse peritoneal macrophages stimulated by A23187. Formation of prostaglandin E-2, leukotriene B-4 and 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE) was significantly inhibited in a concentration-dependent manner. In addition, AGE inhibited lipopolysaccharide-induced nitric oxide production in RAW246.7 macrophages and nuclear factor kappa B activation induced in 293 cells by tumour necrosis factor alpha. |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.1211/jpp.60.7.0017 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257093800017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5154 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xian-Wen,Zeng, Hua-Wu,Liu, Xiao-Hua,et al. Anti-inflammatory and anti-tumour effects of Abies georgei extracts[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2008,60(7):937-941. |
| APA | Yang, Xian-Wen.,Zeng, Hua-Wu.,Liu, Xiao-Hua.,Li, Su-Mei.,Xu, Wen.,...&Zhang, Wei-Dong.(2008).Anti-inflammatory and anti-tumour effects of Abies georgei extracts.JOURNAL OF PHARMACY AND PHARMACOLOGY,60(7),937-941. |
| MLA | Yang, Xian-Wen,et al."Anti-inflammatory and anti-tumour effects of Abies georgei extracts".JOURNAL OF PHARMACY AND PHARMACOLOGY 60.7(2008):937-941. |
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