Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii
Zhu, Hu-Cheng1; Chen, Chun-Mei1; Zhang, Jin-Wen2; Guo, Yi1; Tan, Dong-Dong1; Wei, Guang-Zheng1; Yang, Jing3; Wang, Jian-Ping1; Luo, Zeng-Wei1; Xue, Yong-Bo1; Zhang, Yong-Hui1
2017-05-01
Source PublicationCHINESE CHEMICAL LETTERS
Volume28Pages:986-990
AbstractTwenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii, including two new ones named hyperisampsins N and 0 (1 and 2). The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric analyses. Their absolute configurations were further determined by using TDDFT ECD calculations. Compounds 2, 7, and 8 were evaluated for their cytotoxic activities against five human cancer cell lines, of which, 2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
KeywordHyperisampsin Ppaps Ecd Calculation Absolute Configuration
DOI10.1016/j.cclet.2016.11.014
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000402444600013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51362
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Hu-Cheng,Chen, Chun-Mei,Zhang, Jin-Wen,et al. Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii[J]. CHINESE CHEMICAL LETTERS,2017,28:986-990.
APA Zhu, Hu-Cheng.,Chen, Chun-Mei.,Zhang, Jin-Wen.,Guo, Yi.,Tan, Dong-Dong.,...&Zhang, Yong-Hui.(2017).Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii.CHINESE CHEMICAL LETTERS,28,986-990.
MLA Zhu, Hu-Cheng,et al."Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii".CHINESE CHEMICAL LETTERS 28(2017):986-990.
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