中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron
作者: Kong, Ling-Mei1, 2, 3; Long, Xian-Wen1, 2; Yang, Xing-Wei1, 2; Xia, Fan1, 2, 4, 5; Khan, Afsar6; Yan, Hui1, 2; Deng, Jun1, 2; Li, Xian4, 5; null(许刚)1, 2
刊名: TETRAHEDRON LETTERS
关键词: Polyprenylated acylphloroglucinol ; Hypericum ascyron ; Ascyronones A-D ; Biomimetic transformation
英文摘要: Three new seco-polycyclic polyprenylated acylphloroglucinols (PPAPs), ascyronones A-C (1-3), and a new biosynthetic precursor, ascyronone D (4), were isolated from Hypericum ascyron together with three known analogues (5-7). Compounds 1 and 2, sharing an unusual seven-membered carbon core fused with a gamma-lactone ring, could be derived from 1,9-seco-PPAPs via further rearrangement. A biomimetic transformation from 5 to 1 was performed by using base-driven retro-Claisen and rearrangement cascade reaction, which further confirmed the structure of 1 and shed light to its possible biosynthetic pathway. Interestingly, all these compounds are decorated with a methyl group at C-5 instead of a prenyl or geranyl group in many other PPAPs. The isolates were evaluated for their inhibitory activities against five human tumor cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
出版日期: 2017-05-31
卷号: 58, 期号:22, 页码:2113-2117
DOI标识: 10.1016/j.tetlet.2017.04.044
语种: 英语
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51248
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
1-s2.0-S0040403917304811-main.pdf(599KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
5.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
6.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan

Recommended Citation:
Kong, Ling-Mei,Long, Xian-Wen,Yang, Xing-Wei,et al. seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron[J]. TETRAHEDRON LETTERS,2017,58(22):2113-2117.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Kong, Ling-Mei]'s Articles
[Long, Xian-Wen]'s Articles
[Yang, Xing-Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Kong, Ling-Mei]‘s Articles
[Long, Xian-Wen]‘s Articles
[Yang, Xing-Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 1-s2.0-S0040403917304811-main.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace