| Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway | |
Zheng, Shan-Qing1,2; Huang, Xiao-Bing1,2; Xing, Ti-Kun1,2; Ding, Ai-Jun1,2; Wu, Gui-Sheng1 ; Luo, Huai-Rong1
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| 2017-04-01 | |
| Source Publication | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
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| Volume | 72Issue:4Pages:464-472 |
| Abstract | Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway. |
| Keyword | Chlorogenic Acid Caenorhabditis Elegans Daf-16/foxo Longevity Stress Resistance |
| DOI | 10.1093/gerona/glw105 |
| Indexed By | SCI ; SSCi |
| Language | 英语 |
| WOS Research Area | Geriatrics & Gerontology |
| WOS Subject | Geriatrics & Gerontology ; Gerontology |
| WOS ID | WOS:000402110100002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/51242 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Zheng, Shan-Qing,Huang, Xiao-Bing,Xing, Ti-Kun,et al. Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2017,72(4):464-472. |
| APA | Zheng, Shan-Qing,Huang, Xiao-Bing,Xing, Ti-Kun,Ding, Ai-Jun,Wu, Gui-Sheng,&Luo, Huai-Rong.(2017).Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,72(4),464-472. |
| MLA | Zheng, Shan-Qing,et al."Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 72.4(2017):464-472. |
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| glw105.pdf（6146KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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