DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy
Xu, Min1,2,3; Sun, Peng; Zhang, Ying; Yang, Ci-Hang; Wei, Xin1; Ma, Xiao-Xia1; Yang, Chong-Ren1; Ni, Kun-Ming; Zhang, Ying-Jun1; Li, Xiao-Ming1
2017-05-10
Source PublicationSCIENTIFIC REPORTS
Volume7Pages:1701
AbstractEpilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, which is a natural triterpenoid compound extracted from plants of the Asclepiadaceae family, significantly decreased the incidence and stages of seizures in three classical drug-induced acute seizure models in C57BL/6 mice. Furthermore, we also found that the antiepileptic effect of DV21 might be partly mediated through reducing the excitability of cortical pyramidal neurons by increasing M current, which are low-threshold non-inactivating voltage-gated potassium currents. Moreover, the application of XE991, an inhibitor of M current, could block most the antiepileptic effect of DV21. Taken together, our results indicated that DV21 might be a novel leading compound for the treatment of epilepsy.
DOI10.1038/s41598-017-01734-z
Indexed BySCI
Language英语
WOS IDWOS:000400886100041
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51231
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
2.Kunming Univ Technol & Sci, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Kunming, Peoples R China
3.Kunming Univ Technol & Sci, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Xu, Min,Sun, Peng,Zhang, Ying,et al. DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy[J]. SCIENTIFIC REPORTS,2017,7:1701.
APA Xu, Min.,Sun, Peng.,Zhang, Ying.,Yang, Ci-Hang.,Wei, Xin.,...&Li, Xiao-Ming.(2017).DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.SCIENTIFIC REPORTS,7,1701.
MLA Xu, Min,et al."DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy".SCIENTIFIC REPORTS 7(2017):1701.
Files in This Item: Download All
File Name/Size DocType Version Access License
redirect-nature1.pdf(4545KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, Min]'s Articles
[Sun, Peng]'s Articles
[Zhang, Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, Min]'s Articles
[Sun, Peng]'s Articles
[Zhang, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, Min]'s Articles
[Sun, Peng]'s Articles
[Zhang, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: redirect-nature1.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.