| DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy | |
Xu, Min1,2,3; Sun, Peng; Zhang, Ying; Yang, Ci-Hang; Wei, Xin1; Ma, Xiao-Xia1; Yang, Chong-Ren1; Ni, Kun-Ming; Zhang, Ying-Jun1 ; Li, Xiao-Ming1
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| 2017-05-10 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| 卷号 | 7页码:1701 |
| 摘要 | Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, which is a natural triterpenoid compound extracted from plants of the Asclepiadaceae family, significantly decreased the incidence and stages of seizures in three classical drug-induced acute seizure models in C57BL/6 mice. Furthermore, we also found that the antiepileptic effect of DV21 might be partly mediated through reducing the excitability of cortical pyramidal neurons by increasing M current, which are low-threshold non-inactivating voltage-gated potassium currents. Moreover, the application of XE991, an inhibitor of M current, could block most the antiepileptic effect of DV21. Taken together, our results indicated that DV21 might be a novel leading compound for the treatment of epilepsy. |
| DOI | 10.1038/s41598-017-01734-z |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000400886100041 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51231 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Univ Technol & Sci, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Kunming, Peoples R China 3.Kunming Univ Technol & Sci, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Min,Sun, Peng,Zhang, Ying,et al. DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy[J]. SCIENTIFIC REPORTS,2017,7:1701. |
| APA | Xu, Min.,Sun, Peng.,Zhang, Ying.,Yang, Ci-Hang.,Wei, Xin.,...&Li, Xiao-Ming.(2017).DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.SCIENTIFIC REPORTS,7,1701. |
| MLA | Xu, Min,et al."DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy".SCIENTIFIC REPORTS 7(2017):1701. |
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| redirect-nature1.pdf（4545KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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