Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng)
Zhang, Jian-Gang1,2; Geng, Chang-An1; Huang, Xiao-Yan1; Chen, Xing-Long1,2; Ma, Yun-Bao1; Zhang, Xue-Mei1; Chen, Ji-Jun1
2017-02-01
Source PublicationEUROPEAN JOURNAL OF MASS SPECTROMETRY
Volume23Issue:1Pages:11-21
AbstractUncaria rhynchophylla (Gou-Teng in Chinese) is officially documented in Chinese pharmacopoeia as one of the authentic sources for the crude drug of Gou-Teng which has long been used for mental and cardiovascular diseases. Indole alkaloids are the characteristic constituents responsible for the desired hypotensive effect; however, the psychiatric active constituents of Gou-Teng are still unclear. According to traditional Chinese medicine theory, only the hook-bearing stems of U. rhynchophylla are used as the crude materials for Gou-Teng, while its leaves and fruits are scarcely used. The present study aimed to compare the metabolic fingerprints of different parts (hooks, stems, leaves and fruits) of U. rhynchophylla by LC-DAD-MS/MS analysis and further evaluate their psychiatric activities on HEK293 cell line in vitro. A total of 38 constituents including 26 alkaloids, six flavonoids, two triterpenoids, two chlorogenic acid analogs and two other compounds were characterized. The different parts of U. rhynchophylla can be well differentiated from their chemical profiles. Leaves displayed the most potent activity on both MT1 and MT2 receptors, with agonistic rates of 39.7% and 97.6%. For 5-HT1A and 5-HT2C receptors, hooks showed the strongest activity with agonistic rates of 92.6% and 83.1%, respectively. This investigation provided valuable information for understanding the chemical divergence between different parts of U. rhynchophylla, and their substantial bases for psychiatric purposes.
KeywordUncaria Rhynchophylla Gou Teng Lc-ms Analysis Chemical Profiles Mt1/2 And 5-ht1a/2c Receptors Indole Alkaloids
DOI10.1177/1469066717694044
Indexed BySCI
Language英语
WOS Research AreaPhysics ; Spectroscopy
WOS SubjectPhysics, Atomic, Molecular & Chemical ; Spectroscopy
WOS IDWOS:000399816200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51194
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jian-Gang,Geng, Chang-An,Huang, Xiao-Yan,et al. Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng)[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY,2017,23(1):11-21.
APA Zhang, Jian-Gang.,Geng, Chang-An.,Huang, Xiao-Yan.,Chen, Xing-Long.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2017).Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng).EUROPEAN JOURNAL OF MASS SPECTROMETRY,23(1),11-21.
MLA Zhang, Jian-Gang,et al."Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng)".EUROPEAN JOURNAL OF MASS SPECTROMETRY 23.1(2017):11-21.
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