Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase

doi:10.1038/s41598-017-00925-y

	Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase
	Hu, Rongkuan 1,2,4,6; Yan, Huan 3; Fei, Xiaoyan 6; Liu, Haiyang3 ; Wu, Jiarui 1,2,4,5
	2017-04-10
发表期刊	SCIENTIFIC REPORTS
卷号	7 页码:778
摘要	AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2C12 myotubes by stimulating glucose transporter-4 (GLUT-4) membraned translocation. Treatment of primary mouse hepatocytes with shizukaol F decreased the expression of phosphoenolpyruvate carboxykinase 2 (PEPCK), glucose-6-phosphatase (G6Pase) and suppressed hepatic gluconeogenesis. Meanwhile, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice. Further studies indicated that shizukaol F modulates glucose metabolism mainly by AMPKa phosphorylation activity. In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits respiratory complex I, which may result in AMPK activation. Our results highlight the potential value of shizukaol F as a possible treatment of metabolic syndrome.
DOI	10.1038/s41598-017-00925-y
收录类别	SCI
语种	英语
WOS记录号	WOS:000399071500001
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/51062
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
推荐引用方式 GB/T 7714	Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,et al. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase[J]. SCIENTIFIC REPORTS,2017,7:778.
APA	Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,Liu, Haiyang,&Wu, Jiarui.(2017).Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase.SCIENTIFIC REPORTS,7,778.
MLA	Hu, Rongkuan,et al."Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase".SCIENTIFIC REPORTS 7(2017):778.

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