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题名: Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase
作者: Hu, Rongkuan1, 2, 4, 6; Yan, Huan3; Fei, Xiaoyan6; Liu, Haiyang3; Wu, Jiarui1, 2, 4, 5
刊名: SCIENTIFIC REPORTS
出版日期: 2017-04-10
卷号: 7
DOI: 10.1038/s41598-017-00925-y
文章类型: Article
英文摘要: AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2C12 myotubes by stimulating glucose transporter-4 (GLUT-4) membraned translocation. Treatment of primary mouse hepatocytes with shizukaol F decreased the expression of phosphoenolpyruvate carboxykinase 2 (PEPCK), glucose-6-phosphatase (G6Pase) and suppressed hepatic gluconeogenesis. Meanwhile, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice. Further studies indicated that shizukaol F modulates glucose metabolism mainly by AMPKa phosphorylation activity. In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits respiratory complex I, which may result in AMPK activation. Our results highlight the potential value of shizukaol F as a possible treatment of metabolic syndrome.
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SKELETAL-MUSCLE ; METFORMIN ; ROSIGLITAZONE ; INCREASE ; AICAR ; GLUCONEOGENESIS ; ADIPOCYTES ; INHIBITION ; EXPRESSION ; OXIDATION
收录类别: SCI
项目资助者: National Natural Science Foundation of China(31130034 ; 31470808 ; 81072543)
语种: 英语
WOS记录号: WOS:000399071500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51062
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
6.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
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