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题名: Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata
作者: Yu, Fei-Xue1, 2; Li, Zhe3; Chen, Yao2; Yang, Yin-He3; Li, Guo-Hong1; Zhao, Pei-Ji1, 3
刊名: FITOTERAPIA
出版日期: 2017-03-01
卷号: 117, 页码:41-46
关键词: Huperzia serrata ; Endophytic fungus ; Chaetomium sp M453 ; C25 steroids ; X-ray ; Structure identification
DOI: 10.1016/j.fitote.2016.12.012
文章类型: Article
英文摘要: An endophytic fungus, Chaetomium sp. M453, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation. Three unusual C25 steroids, neocyclocitrinols E -G (1-3), and 3 beta-hydroxy-5,9-epoxy-(22E,24R)-ergosta-7,22-dien-6-one (4) together with three known steroids were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS experiments. The absolute configuration of 1 was determined by X-ray crystallographic analysis and CD analyses. The acetylcholinesterase inhibitory activities of compounds 1-4 were tested in vitro. Compound 4 showed weak acetylcholinesterase inhibitory activity. (C) 2016 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PENICILLIUM-CITRINUM ; PLANTS ; 20-HYDROXYECDYSONE ; CONVERSION ; YEW
收录类别: SCI
项目资助者: "973" Program of China(2013CB127505) ; NSFC(31560016 ; Applied Basic Research Foundation of Yunnan Province(2013FA018) ; 31360028)
语种: 英语
WOS记录号: WOS:000395852600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51018
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Minist Educ, Key Lab Microbial Divers Southwest China, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650091, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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