Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata
Yu, Fei-Xue1,2; Li, Zhe3; Chen, Yao2; Yang, Yin-He3; Li, Guo-Hong1; Zhao, Pei-Ji1,3
2017-03-01
Source PublicationFITOTERAPIA
Volume117Pages:41-46
AbstractAn endophytic fungus, Chaetomium sp. M453, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation. Three unusual C25 steroids, neocyclocitrinols E -G (1-3), and 3 beta-hydroxy-5,9-epoxy-(22E,24R)-ergosta-7,22-dien-6-one (4) together with three known steroids were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS experiments. The absolute configuration of 1 was determined by X-ray crystallographic analysis and CD analyses. The acetylcholinesterase inhibitory activities of compounds 1-4 were tested in vitro. Compound 4 showed weak acetylcholinesterase inhibitory activity. (C) 2016 Elsevier B.V. All rights reserved.
KeywordHuperzia Serrata Endophytic Fungus Chaetomium Sp M453 C25 Steroids X-ray Structure Identification
DOI10.1016/j.fitote.2016.12.012
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000395852600008
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51018
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Minist Educ, Key Lab Microbial Divers Southwest China, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650091, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Yu, Fei-Xue,Li, Zhe,Chen, Yao,et al. Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata[J]. FITOTERAPIA,2017,117:41-46.
APA Yu, Fei-Xue,Li, Zhe,Chen, Yao,Yang, Yin-He,Li, Guo-Hong,&Zhao, Pei-Ji.(2017).Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata.FITOTERAPIA,117,41-46.
MLA Yu, Fei-Xue,et al."Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata".FITOTERAPIA 117(2017):41-46.
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