| Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata | |
| Yu, Fei-Xue1,2; Li, Zhe3; Chen, Yao2; Yang, Yin-He3; Li, Guo-Hong1; Zhao, Pei-Ji1,3 | |
| 2017-03-01 | |
| 发表期刊 | FITOTERAPIA
 |
| 卷号 | 117页码:41-46 |
| 摘要 | An endophytic fungus, Chaetomium sp. M453, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation. Three unusual C25 steroids, neocyclocitrinols E -G (1-3), and 3 beta-hydroxy-5,9-epoxy-(22E,24R)-ergosta-7,22-dien-6-one (4) together with three known steroids were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS experiments. The absolute configuration of 1 was determined by X-ray crystallographic analysis and CD analyses. The acetylcholinesterase inhibitory activities of compounds 1-4 were tested in vitro. Compound 4 showed weak acetylcholinesterase inhibitory activity. (C) 2016 Elsevier B.V. All rights reserved. |
| 关键词 | Huperzia Serrata Endophytic Fungus Chaetomium Sp M453 C25 Steroids X-ray Structure Identification |
| DOI | 10.1016/j.fitote.2016.12.012 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395852600008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51018 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Minist Educ, Key Lab Microbial Divers Southwest China, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650091, Peoples R China 2.Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Fei-Xue,Li, Zhe,Chen, Yao,et al. Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata[J]. FITOTERAPIA,2017,117:41-46. |
| APA | Yu, Fei-Xue,Li, Zhe,Chen, Yao,Yang, Yin-He,Li, Guo-Hong,&Zhao, Pei-Ji.(2017).Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata.FITOTERAPIA,117,41-46. |
| MLA | Yu, Fei-Xue,et al."Four new steroids from the endophytic fungus Chaetomium sp M453 derived of Chinese herbal medicine Huperzia serrata".FITOTERAPIA 117(2017):41-46. |
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| yu2016.pdf（450KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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