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题名: Ent-Abietanoids Isolated from Isodon serra
作者: Wan, Jun1, 2; Jiang, Hua-Yi1, 2; Tang, Jian-Wei1, 2; Li, Xing-Ren1, 2; Du, Xue1; null(李艳)1; Sun, Han-Dong1; Pu, Jian-Xin1
刊名: MOLECULES
关键词: Isodon serra ; ent-abietane diterpenoids ; anti-inflammation ; cytotoxicity
英文摘要: Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3,14)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 M) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).
出版日期: 2017-02-01
卷号: 22, 期号:2, 页码:309
DOI标识: 10.3390/molecules22020309
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/50994
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China

Recommended Citation:
Wan, Jun,Jiang, Hua-Yi,Tang, Jian-Wei,et al. Ent-Abietanoids Isolated from Isodon serra[J]. MOLECULES,2017,22(2):309.
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