Ent-Abietanoids Isolated from Isodon serra
Wan, Jun1,2; Jiang, Hua-Yi1,2; Tang, Jian-Wei1,2; Li, Xing-Ren1,2; Du, Xue1; Li, Yan1; Sun, Han-Dong1; Pu, Jian-Xin1
2017-02-01
Source PublicationMOLECULES
Volume22Issue:2Pages:309
AbstractFour new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3,14)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 M) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).
KeywordIsodon Serra Ent-abietane Diterpenoids Anti-inflammation Cytotoxicity
DOI10.3390/molecules22020309
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000395552400123
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/50994
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wan, Jun,Jiang, Hua-Yi,Tang, Jian-Wei,et al. Ent-Abietanoids Isolated from Isodon serra[J]. MOLECULES,2017,22(2):309.
APA Wan, Jun.,Jiang, Hua-Yi.,Tang, Jian-Wei.,Li, Xing-Ren.,Du, Xue.,...&Pu, Jian-Xin.(2017).Ent-Abietanoids Isolated from Isodon serra.MOLECULES,22(2),309.
MLA Wan, Jun,et al."Ent-Abietanoids Isolated from Isodon serra".MOLECULES 22.2(2017):309.
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