Novel Indole Alkaloid from the Flowers of Rauvolfia yunnanensis
Wang Hai-Bo; Liu Xi-Kui
AbstractRauvolfia yunnanensis Tsiang are commonly used as a folklore herb to treat hypertension, snake bites, and insanity in the southwest of China, and an important industrial raw material of reserpine. The phytochemical constituents of the rhizome of it have been investigated intensively. Reserpine and yohimbine are two effective biological activities compounds isolated from the rhizome of Rauvolfia yunnanensis. But the wild resources of it reduced gradually in recent years, thus we have introduced and cultivated it to the arid hot valley region of Yunnan. China, and investigated the chemical constituents variety of it for the sustainable utilization. In the present work, the chemical-constituents of the flowers of R. yunnanensis have been investigated for extending the utilizable efficiency of resources. The dried flowers powder(1.0 kg) of R. yunnanensis was extracted with 95% EtOH(10 L x 6, 48 h each) at room temperature, and then extracted successively with EtOAc(1 L x 6). The EtOAc portion(50 g) led to the isolation of nine compounds by column chromatography (silica, alumina and Sephadex LH-20 gel) methods. Their structures were identified as(18Z)-11-methoxypicrinine(1), caberoline(2), 11-methoxystrictamine(3), strictamine(4), russulamide(5), ursolic acid (6), urs-12 (13)-en-3 alpha-yl acetate(7), beta-amyryl nonanoate(8) and beta-sitosterol (9) by spectral analysis(UV, IR, MS and ID, 2D NMR), respectively. Among them, compound 1 is a new indole alkaloids, compounds 5, 7 and 8 are firstly isolated from it. But reserpine and yohimbine haven't been isolated.
KeywordRauvolfia Yunnanensis Indole Alkaloid (18z)-11-methoxypicrinine Russulamide
Subject AreaChemistry, Multidisciplinary
Indexed BySCI
WOS IDWOS:000283634600019
Citation statistics
Document Type期刊论文
AffiliationChinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
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GB/T 7714
Wang Hai-Bo,Liu Xi-Kui. Novel Indole Alkaloid from the Flowers of Rauvolfia yunnanensis[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2010,31(10):2005-2009.
APA Wang Hai-Bo,&Liu Xi-Kui.(2010).Novel Indole Alkaloid from the Flowers of Rauvolfia yunnanensis.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,31(10),2005-2009.
MLA Wang Hai-Bo,et al."Novel Indole Alkaloid from the Flowers of Rauvolfia yunnanensis".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31.10(2010):2005-2009.
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