Indole Alkaloids from the Leaves of Rauvolfia yunnanensis
Geng Chang-An1,2; Liu Xi-Kui1
AbstractRauvolfia yuananensis Tsiang are commonly used as a folklore herb to treat hypertension, snake bites, and insanity in the southwest of China, and an important industrial raw material of reserpine and vertical. But the wild resources of it reduced gradually in recent years, thus we have introduced and cultivated it to the arid-hot valley region of Yunnan Province, China, and investigated the chemical constituents variety of it for the sustainable utilization. The dried leaves powder (8.0 kg) of R. yunnanensis was extracted with 95% (volume fraction) EtOH(40 L x5, 8 h each), and led to the isolation of eleven indole alkaloids by column chromatography (silica, alumina and Sephadex LH-20 gel) methods. Their structures were identified as caberine (1), 19-ethoxyl-demethyl-Delta'-17-acetylajmaline(2), vellosimine(3), beta-yohimbine(4), yohimbine(5), vinorine(6), picrinine(7), nareline (8), akuammicine(9), strictamine(10), reserpine(11) by spectral analysis (UV, IR, MS and 1 D, 2D NMR), respectively. Among them, compound 2 was a new indole alkaloids, compounds 1, 8 and 9 were firstly isolated from this plant.
KeywordRauvolfia Yunnanensis Indole Alkaloid 19-ethoxyl-1-demethyl-delta '-acetylajmaline Caberine Reserpine Yohimbine
Subject AreaChemistry, Multidisciplinary
Indexed BySCI
WOS IDWOS:000277223700022
Citation statistics
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Geng Chang-An,Liu Xi-Kui. Indole Alkaloids from the Leaves of Rauvolfia yunnanensis[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2010,31(4):731-735.
APA Geng Chang-An,&Liu Xi-Kui.(2010).Indole Alkaloids from the Leaves of Rauvolfia yunnanensis.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,31(4),731-735.
MLA Geng Chang-An,et al."Indole Alkaloids from the Leaves of Rauvolfia yunnanensis".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31.4(2010):731-735.
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