|其他摘要||The chemical constituents of six higher fungi including Lactarius deliciosus, Albatrellus confluens, Albatrellus dispansus, Polyporus elegans, Hydnellum concrescens and Xylaria nigripes collected from Yunnan Province, P. R. China, and two medicinal plants including Morinda citrifolia (Rubiaceae) and Psidium guajava (Myrtaceae) collected from south of Vietnam, were investigated.
More than 140 compounds, including 102 different compounds and 7 new ones (containing an unprecedented carbon skeleton), have been obtained using varied chromatographic methods, and the structures of new metabolites were elucidated by extensive spectroscopic analysis (1D-NMR, 2D-NMR, MS, HR-MS, IR, UV/Vis).
Several azulene pigments including three new ones were isolated from the fruiting bodies of the basidiomycete Lactarius deliciosus. The latex of the fruiting bodies of L. deliciosus is firstly carrot-colored, but slowly (minutes) darkens and eventually turns green, and these colors in L. deliciosus have previously been shown to be due to guaiane sesquiterpenes.
A series of dimeric grifolin pigments including one new compound were isolated from the fruiting bodies of the basidiomycete Albatrellus confluens. These pigments are rarely found in nature except for only two according to the literatures. Preliminary biological assay showed that albatrellin (57) exhibited cytotoxic activity against HepG2 human lung carcinoma cell with IC50 value of 1.55 µg ml-1(positive control DDP with IC50 value of 0.28µg ml-1).
Two unusual meroterpenoids, named diguajadial (13) and guajadial (16), were isolated from the leaves of Psidium guajava (Myrtaceae). These compounds maybe form through Diels-Alder reaction with two units (β-caryophyllene and highly oxidized unit). Compound 16 is symmetric homodimeric ether comprising two guajadial units.
A new acridone alkaloid (74) was isolated from Micromelum integerrimum. This kind of alkaloids, a group of important bioactive compounds, are mainly existed in the citrus plant of Rutaceae family, which exhibited the activites of anticancer, antitumour, antivirus, antiproliferation and anti-malaria, et al.|