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Molecular cloning and sequence characterization of two genes, DQA1 and DQA2, from the Chinese yakow (Bos grunniens x Bos taurus)
Xi, Dongmei1,2; Memon, Sameeullah1,2; Li, Guozhi1,2; Liu, Xiangying1,2; Su, Chao1,2; Leng, Jing1,2; Wang, Liping1,2; Khan, Sehroon3,4; Deng, Weidong1,2
2017
Source PublicationTURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
Volume41Issue:1Pages:136-141
AbstractThe major histocompatibility complex (MHC) plays a crucial role in the immune response to infectious diseases. The aim of the present study was to investigate the structural and functional characteristics and possible duplication of the MHC-DQA genes in the Chinese yakow, which is well adapted to the Qinghai-Tibetan Plateau. Two full-length cDNA sequences and partial 5'-and 3'-untranslated regions (UTRs) were retrieved and denoted as BogrxBoLA-DQA star 0101 (DQA1) and BogrxBoLA-DQA star 2001 (DQA2), respectively. The percentage of nucleotide and amino acid sequences homology between BogrxBoLA-DQA1 and BogrxBoLA-DQA2 showed that these two sequences have more identity to alleles of the corresponding DQA1 and DQA2 genes from other counterparts than to each other. Moreover, the BogrxBoLA-DQA1 and -DQA2 exhibited considerable variation with 99 nucleotide polymorphisms along the length of the coding regions, leading to 52 amino acid polymorphisms. The phylogenetic tree investigation also demonstrated that there is a larger genetic gap within these two identified genes than within orthologous genes from different animals, suggesting that these sequences belong to nonallelic and duplicated types in the Chinese yakow. This is the first report to isolate and identify the MHC-DQA1 and-DQA2 genes. This result will deepen our understanding of MHC diversity among different ruminant species based on comparative population genetics.
KeywordMajor Histocompatibility Complex (Mhc) Chinese Yakow (Bos Grunniens x Bos Taurus) Dqa1 And Dqa2 Genes Molecular Structure And Function
DOI10.3906/vet-1510-86
Indexed BySCI
Language英语
WOS Research AreaVeterinary Sciences
WOS SubjectVeterinary Sciences
WOS IDWOS:000394568600019
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/46048
Collection资源植物与生物技术所级重点实验室
Affiliation1.Yunnan Agr Univ, Yunnan Prov Key Lab Anim Nutr & Feed, Kunming, Peoples R China
2.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming, Peoples R China
3.Chinese Acad Sci, Ctr Mt Ecosyst Studies, Kunming Inst Bot, Kunming, Peoples R China
4.World Agroforestry Ctr East & Cent Asia, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Xi, Dongmei,Memon, Sameeullah,Li, Guozhi,et al. Molecular cloning and sequence characterization of two genes, DQA1 and DQA2, from the Chinese yakow (Bos grunniens x Bos taurus)[J]. TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES,2017,41(1):136-141.
APA Xi, Dongmei.,Memon, Sameeullah.,Li, Guozhi.,Liu, Xiangying.,Su, Chao.,...&Deng, Weidong.(2017).Molecular cloning and sequence characterization of two genes, DQA1 and DQA2, from the Chinese yakow (Bos grunniens x Bos taurus).TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES,41(1),136-141.
MLA Xi, Dongmei,et al."Molecular cloning and sequence characterization of two genes, DQA1 and DQA2, from the Chinese yakow (Bos grunniens x Bos taurus)".TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES 41.1(2017):136-141.
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