| Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats | |
| Zhao, Yi1,2; Liu, Yan1,2; Lan, Xi-Ming1,2; Xu, Guo-Liang1,2; Sun, You-Zhi3; Li, Fei4; Liu, Hong-Ning1,2 | |
| 2016 | |
| 发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 页码 | 1213090 |
| 摘要 | Dendrobium officinale (Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of Dendrobium officinale. However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect of Dendrobium officinale on cancer, and its pharmacological mechanism was explored. Dendrobium officinale extracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose of Dendrobium officinale extracts significantly inhibited the rate of carcinogenesis. Further analysis revealed that Dendrobium officinale extracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer. |
| DOI | 10.1155/2016/1213090 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000392004500001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/45635 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev BasicTheory Tradit Chi, Nanchang 330004, Jiangxi, Peoples R China 2.Jiangxi Prov Key Lab TCM Etiopathogenisis, Nanchang 330004, Jiangxi, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Sch Basic Med Sci, Nanchang 330004, Jiangxi, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yi,Liu, Yan,Lan, Xi-Ming,et al. Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016:1213090. |
| APA | Zhao, Yi.,Liu, Yan.,Lan, Xi-Ming.,Xu, Guo-Liang.,Sun, You-Zhi.,...&Liu, Hong-Ning.(2016).Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,1213090. |
| MLA | Zhao, Yi,et al."Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016):1213090. |
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| 1213090.pdf（1947KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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