Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats
Zhao, Yi1,2; Liu, Yan1,2; Lan, Xi-Ming1,2; Xu, Guo-Liang1,2; Sun, You-Zhi3; Li, Fei4; Liu, Hong-Ning1,2
2016
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
页码1213090
摘要Dendrobium officinale (Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of Dendrobium officinale. However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect of Dendrobium officinale on cancer, and its pharmacological mechanism was explored. Dendrobium officinale extracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose of Dendrobium officinale extracts significantly inhibited the rate of carcinogenesis. Further analysis revealed that Dendrobium officinale extracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer.
DOI10.1155/2016/1213090
收录类别SCI
语种英语
WOS记录号WOS:000392004500001
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/45635
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev BasicTheory Tradit Chi, Nanchang 330004, Jiangxi, Peoples R China
2.Jiangxi Prov Key Lab TCM Etiopathogenisis, Nanchang 330004, Jiangxi, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Sch Basic Med Sci, Nanchang 330004, Jiangxi, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Zhao, Yi,Liu, Yan,Lan, Xi-Ming,et al. Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016:1213090.
APA Zhao, Yi.,Liu, Yan.,Lan, Xi-Ming.,Xu, Guo-Liang.,Sun, You-Zhi.,...&Liu, Hong-Ning.(2016).Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,1213090.
MLA Zhao, Yi,et al."Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016):1213090.
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