|其他摘要||The thesis includes three chapters. Chapters 1 and 2 cover chemical constituents of Faeces trogopterori and Brachystemma calycinum. 64 compounds were isolated in total, and 16 of which are new. New compounds include seven new diterpenoids (isopimarane-, abietane- and totarane-types), three new furan derivatives, one norlignan, and one new alkaloid. Chapter 3 reviews cyclopeptide constituents from Caryophyllaceae plants.
Faeces trogopterori, the dung of Trogopterus xanthipes and a basilic constituent of ten prescriptions (including three Tibetan ones) recorded in Pharmacopoeia of the People’s Republic of China (2005), has been used in traditional Chinese medicine for the treatment of blood stasis and pain. Because of the excretion of Trogopterus xanthipes, Faeces trogopterori couldn’t be aceeptably used in present clinic. Actually, Faeces trogopterori may contain small molecules produced by Trogopterus xanthipes bio-transformation in vivio. From EtOAc soluable extract of the material, seven new diterpenoids, one new norlignan, together with 26 known compounds were obtained by chromatographic methods. Their structures were determined by spectroscopic methods, which were trogopteroids A－G (1－3, 12－15), isopimara-8(14),15-dien-3-one (4), isopimara-7,15-dien-3-one (5), 19-norisopimara-8(14),15-dien-3-one (6), 8b-hydroxy-15-isopimaren-3-one (7), isopimara-8(14),15-dien-3β-ol (8), isopimara-7(8),15-dien-3β-ol (9), isopimara-8（9）,15-dien-3β-ol (10), akhdardiol (11),
sempervirol (16), macrophynin E (17), triptobenzene B (18), ferruginol (19), 8,11,13-totaratriene-3,13-diol (20), 18-hydroxyferruginol (21), 3,3'-(3-hydroxypropane-1,2-diyl)diphenol (22), trans-2-(3,5-dihydroxybenzyl)-3-(3-hydroxybenzyl)-γ-butyrolactone (23), tocopherylquinone (24), 5-α-stigmastan-3-one (25), 5-α-ergostan-3-one (26), stigmast-4-en-3-one (27), ergost-4-en-3-one (28), cholest-4-en-3-one (29), 6β-hydroxycholest-4-en-3-one (30), 6β-hydroxyergost-4-en-3-one (31), 6β-hydroxystigmast-4-en-3-one (32), 3,12-cedranediol (33), 4-hydroxybenzaldehyde(34), respectively.
B. calycinum (Caryophyllaceae) is widely distributed in India, Nepal, Vietnam, Laos, Cambodia, and the southwest of China, which is one plant from Brachystemma genus. The root of this plant has been used as traditional Chinese medicine used for rheumatism1imb numbness，impotence and foot edema. In order to find the immunosuppressive constituents and study structure-activity relationship, we collected the material in Xishuangbanna of Yunnan Province, P. R. China and investigate its chemical components. From EtOAc soluable extract of the aerial parts, four new cyclopeptides, three furan derivatives, one alkaloid, together with 22 known compounds were obtained by chromatographic methods. Their structures were determined by spectroscopic methods, each was Brachystemin I－M (1－5), Brachystemin A (6)，Brachystemin C (7), Brachystemidine F (8), Brachystemidine G (9), Brachystemidine A－B (10－11), Brachystemidine D (12), Brachystemol A－C (13－15), 3-furancarboxylic acid (16), 7α-hydroxylambertianic acid (17), Loliolide (18), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (19), 6,9-dihydroxy-4,7-megastigmadien-3-one (20), 9-O-D-Glucopyranoside (21), Ethyl α-D-arabinofuranoside (22), Ethyl α-D-glucopyranoside (23), ω-hydroxypropioquaiacone (24), 4-O-(4-hydroxy-E-cinnamoyl)-ethylic ester (25), 4-O-(4-hydroxy-E-cinnamoyl)-ethylic ester (26), 4-hydrxo-3-methoxy benzoic acid (27), 4-hydroxybenzaldehyde (28), 2-minaline (29), 1,7-heptanedicarboxylic acid (30), 4-ene-2,8-octanedicarboxylic acid (31), Glycerol 1-(9 Z-octadecenoate) (32)。
Chapter 3 summarized cyclopeptides from Caryophyllaceae plants up to 2008.|