Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum
Shi, Yan-Ni1,2; Liu, Fang-Fang1,3; Jacob, Melissa R.4; Li, Xing-Cong4; Zhu, Hong-Tao1,5; Wang, Dong1,5; Cheng, Rong-Rong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1,5
2017
Source PublicationPLANTA MEDICA
Volume83Issue:01-02Pages:143-150
AbstractSixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3-hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90113 with IC50 values in the range between 4.7 and 20.0 mu g/mL.
KeywordPiper Flaviflorum Piper Sarmentosum Piperaceae Amide Alkaloids Antifungal Activity
DOI10.1055/s-0042-109778
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000393182100018
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/41890
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming, Peoples R China
4.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
5.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Shi, Yan-Ni,Liu, Fang-Fang,Jacob, Melissa R.,et al. Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum[J]. PLANTA MEDICA,2017,83(01-02):143-150.
APA Shi, Yan-Ni.,Liu, Fang-Fang.,Jacob, Melissa R..,Li, Xing-Cong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2017).Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.PLANTA MEDICA,83(01-02),143-150.
MLA Shi, Yan-Ni,et al."Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum".PLANTA MEDICA 83.01-02(2017):143-150.
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