|其他摘要||Five chapters are included in this dissertation. The first chapter presented the investigation on chemical constituents from ‘Yi’ ethno-medicinal plants Incarvillea arguta and the in vitro anti-inflammatory activity of the new compound. From the second to fourth chapter, the chemical investigations on three species of ‘Dai’ ethno-medicinal plants were introduced, which included Ricinus communis, Rotala rotundifolia and Melia azedarach. In the last chapter, we summarize the limonoids from Meliaceae on their chemistry and biological activities, and 890 compounds in 551 references were cited.
Based on column chromatography and LH-20 separation means and spectra analysis, seventy-six compounds were isolated from the above four species of ethno-medicinal plants, which included fourteen new ones.
Chapter 1 Chemical constituents from Incarvillea arguta
The extracts of the whole plants of Incarvillea arguta (Bignoniaceae), which was called “Liweila”, “Wabuyou” and “Caotianguan”, were mainly used to treat hepatitis, pharyngitis (by decoction drinking) and rheumatism (by pasting on the lesion) by the local ‘Yi’ people in Yunnan and Sichuan Province, P. R. China. From the AcOEt extractive layer of the MeOH extracts of the aerial parts of the plants, we isolated nineteen compounds including one new spirovetivane-type sesquiterpenoid (1), which showed strong in vitro anti-inflammatory activity against Cox-1 and Cox-2 and negative effects against 5-Lox.
Chapter 2 Chemical constituents from Ricinus communis
Ricinus communis L. (Euphorbiaceae), which was called ‘mahongliang’ by the local ‘Dai’ people in Yunnan province, P. R. China, was mainly used for the treatment of icteric hepatitis, arthritis and constipation. Recent researches have revealed the antifertility and inhibitory activity to HIV-1 reverse transcriptase of the constituents from this plant. As to find out the chemical basis of the favorable therapeutic effects, we have chemically investigated the aerial parts of Ricinus communis L., which led to the isolation of twenty-two compounds including four new ones. Among them, compound (5) was a lupane-type triterpenoid, (13) was a tocopherol-related compound, (14) and (15) were casbane-type macrocyclic diterpenoids.
Chapter 3 Chemical constituents from Rotala rotundifolia
Rotala rotundifolia (Lythraceae), which was called “Yaluopeng” by the local ‘Dai’ people, has been used for treatment of carbuncle, furuncle, rheumatism and arthralgia in Yunnan province, China. Furthermore, recent investigation showed its antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus diphtheriae. From the AcOEt extractive layer of the MeOH extracts of the aerial parts of Rotala rotundifolia, we isolated nine compounds, which include a new C13-isoprene derivative (1).
Chapter 4 Chemical constituents from Melia azedarach
Melia azedarach (Meliaceae) was famous for its antifeedant activity of the limonoids in it. The EtOH extracts of the bark of this plant showed anesthesia and inhibitory activities for Ascaris suis. Toosendanin, the main effective constituent, can cause respiratory failure in case of large dose. From the AcOEt extractive layer of the EtOH extracts of the bark of Melia azedarach, we isolated twenty-six compounds including eight new ones. Among them, compounds (5)-(8) and (15) were new triterpenoids and (20)-(22) were new sterols.
Chapter 5 Meliaceous limonoids: chemistry and biological activities
Limonoids (tetranortriterpenoids) are well known for their high degree of oxidation, multiform seco-styles, and their diverse biological activities. This review covered literature from 1961 to 2007, and 551 references 890 compounds were cited.|