Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer
Ma, Liang1,2; Wen, Zhe-Sheng3; Liu, Zi1; Hu, Zheng4; Ma, Jun3; Chen, Xiao-Qin3; Liu, Yong-Qiang1; Pu, Jian-Xin5; Xiao, Wei-Lie5; Sun, Han-Dong5; Zhou, Guang-Biao1
2011-05-31
发表期刊PLOS ONE
ISSN1932-6203
卷号6期号:5页码:e20159
摘要Background: Lung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. However, whether CIP2A can be a new drug target for lung cancer is largely unclear.
关键词Gastric-cancer Breast-cancer Phospho-akt Smoking Cells Carcinoma Survival Leukemia China
资助信息National Key Program for Basic Research (973)[2010CB529201]; Chinese Academy of Sciences[KSCX1-YW-R-26, KSCX2-YW-R-235]; National Natural Science Foundation of China[81071930, 30871110]; National Major Scientific and Technological Program for Drug Discovery[2009ZX09103-101]; Science and Technology Planning Project of Guangzhou[2009Y-C011-2]
学科领域Biology
DOI10.1371/journal.pone.0020159
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000291097600025
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/3968
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Div Mol Carcinogenesis & Targeted Therapy Canc, Beijing, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
3.Sun Yat Sen Univ, Canc Hosp, Guangzhou 510275, Guangdong, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
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Ma, Liang,Wen, Zhe-Sheng,Liu, Zi,et al. Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer[J]. PLOS ONE,2011,6(5):e20159.
APA Ma, Liang.,Wen, Zhe-Sheng.,Liu, Zi.,Hu, Zheng.,Ma, Jun.,...&Zhou, Guang-Biao.(2011).Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer.PLOS ONE,6(5),e20159.
MLA Ma, Liang,et al."Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer".PLOS ONE 6.5(2011):e20159.
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