New pregnane saponins from Ecdysanthera rosea and their cytotoxicity
Zhu, Xiangdong1,2; Wu, Guisheng1; Xiang, Jianying3; Luo, Huairong1; Luo, Shide1; Zhu, Hongmei4; Wang, Yifen1
2011-06-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号82期号:4页码:632-636
摘要Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2. (C) 2011 Elsevier B.V. All rights reserved.
关键词Ecdysanthera Rosea Pregnane Saponin Ecdysantheroside b Cytotoxicity
资助信息National Natural Science Foundation[30860037, 20872148]; Department of Science and Technology in Yunnan Province[20080A007]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2011.01.022
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291140800018
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/3940
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Jiangxi Agr Univ, Coll Biosci & Bioengn, Nanchang 330045, Peoples R China
3.Chinese Acad Sci, Key Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
4.Xiamen Univ, Coll Oceanog & Environm Sci, Xiamen 361000, Peoples R China
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Zhu, Xiangdong,Wu, Guisheng,Xiang, Jianying,et al. New pregnane saponins from Ecdysanthera rosea and their cytotoxicity[J]. FITOTERAPIA,2011,82(4):632-636.
APA Zhu, Xiangdong.,Wu, Guisheng.,Xiang, Jianying.,Luo, Huairong.,Luo, Shide.,...&Wang, Yifen.(2011).New pregnane saponins from Ecdysanthera rosea and their cytotoxicity.FITOTERAPIA,82(4),632-636.
MLA Zhu, Xiangdong,et al."New pregnane saponins from Ecdysanthera rosea and their cytotoxicity".FITOTERAPIA 82.4(2011):632-636.
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