|其他摘要||This thesis elaborated the chemical constituents of two traditional Chinese medicines: processed notoginseng and Guangdong Tuniuxi. By various separation materials and techniques, 42 compounds, including 6 new ones, were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods. The types of these compounds include triterpenoidal saponins and aglycones, lignans, benzofurans, aliphatics, and cholesterols. On the basis of chemical research, the processed methods for notoginseng were studied, and an optimized method was established. Finally, plant resources of Niuxi and their chemical constituents were summarized.
Chapter 1 The Chemical Constituents of Processed Notoginseng. Notoginseng, the root of Panax notoginseng (Burk.) F. H. Chen (Araliaceae), is a traditional Chinese medicine, which is used both in raw and processed forms due to their different pharmacological activities. Detailed chemical investigation on the ethanolic extacts of processed notoginseng led to the isolation of 31 compounds, including 5 new ones: notoginsenosides ST-1 to ST-5 (1-5). The types of these compounds include dammarane saponins (1-25) and their aglycones (26-28), and aliphatics (29-30). Compared with the main constituents of raw notoginseng (ginsenosides Rg1, Rb1, Rd, Re and notoginsenoside R1), the main constituents of processed notoginseng were the less polar constituents (such as ginsenosides Rg3, Rg5, Rh1, Rh4, Rk1 and Rk3). This work will provide basis for the advanced research on the changes of pharmacological activities of processed notoginseng. Moreover, the processing method for notoginseng was studied by HPLC analysis. An optimized method was established.
Chapter 2 The Chemical Constituents of Guangdong Tuniuxi. Guangdong Tuniuxi is the dried roots and rhizomes of Eupatorium chinense L. It is a famous folk medicine in treating diphtheria and bronchitis. The methanolic extract of Guangdong Tuniuxi was studied, and 11 compounds were identified, including a new acetylated lignan (1). The isolated compounds refer to triterpenoidal saponins, lignans, benzofurans, aliphatics, and cholesterols.
Chapter 3 Plant Resources of Niuxi and Their chemical Constituents. The plant resources of Niuxi and their chemical constituents were summarized.|