| Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata | |
Lei, Chun1; Zhang, Lai-Bin1; Yang, Jing2 ; Gao, Li-Xin3; Li, Jing-Ya3; Li, Jia3; Hou, Ai-Jun1
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| 2016-12-07 | |
| 发表期刊 | TETRAHEDRON LETTERS
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| 卷号 | 57期号:49页码:5475-5478 |
| 摘要 | Macdentichalcone (1), an unprecedented polycyclic dimeric chalcone featuring a unique quinonoid moiety, was isolated from Macaranga denticulate, together with 1-(5,7-dihydroxy-2,2,6-trimethy1-2H1-benzopyran-8-y1)-3-pheny1-2-propen-1-one (2), a known monomeric chalcone proposed as a biosynthetic precursor of 1. The structure of 1 was elucidated by extensive spectroscopic analysis including NMR and MS data, as well as calculation of C-13 NMR chemical shifts. Both compounds 1 and 2 showed inhibitory activity against PTP1B in vitro. (C) 2016 Elsevier Ltd. All rights reserved. |
| 关键词 | Macaranga Denticulate Euphorbiaceae Dimeric Chalcone Macdentichalcone Protein Tyrosine Phosphatase 1b |
| DOI | 10.1016/j.tetlet.2016.10.090 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389096600015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33746 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Chun,Zhang, Lai-Bin,Yang, Jing,et al. Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata[J]. TETRAHEDRON LETTERS,2016,57(49):5475-5478. |
| APA | Lei, Chun.,Zhang, Lai-Bin.,Yang, Jing.,Gao, Li-Xin.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2016).Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata.TETRAHEDRON LETTERS,57(49),5475-5478. |
| MLA | Lei, Chun,et al."Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata".TETRAHEDRON LETTERS 57.49(2016):5475-5478. |
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