| Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation | |
| Wu, Jingjing1; Lei, Hu2; Zhang, Jinfu2; Chen, Xiangyun1; Tang, Caixia2; Wang, Weiwei2; Xu, Hanzhang2; Xiao, Weilie3; Gu, Wenli1; Wu, Yingli2 | |
| 2016-09-13 | |
| 发表期刊 | ONCOTARGET
 |
| 卷号 | 7期号:37页码:58995-59005 |
| 摘要 | SUMO-specific protease 1 (SENP1), a member of the de-SUMOylation protease family, is elevated in prostate cancer (PCa) cells and is involved in PCa pathogenesis. Momordin Ic (Mc), a natural pentacyclic triterpenoid, inhibited SENP1 in vitro, as reflected by reduced SENP1C-induced cleavage of SUMO2-Delta RanGAP1. Mc also altered the thermal stability of SENP1 in a newly developed cellular thermal shift assay, indicating that Mc directly interacts with SENP1 in PCa cells. Consistent with SENP1 inhibition, Mc increased SUMOylated protein levels, which was further confirmed by the accumulation of two known SUMOylated proteins, hypoxia inducible factor-1a and nucleus accumbens associated protein 1 in PC3 cells. Compared to LNCaP and normal prostate epithelial RWPE-1 cells, PC3 cells had higher levels of SENP1 mRNA and were more sensitive to Mc-induced growth inhibition. Mc also reduced SENP1 mRNA levels in PCa cells. Overexpression of SENP1 rescued PC3 cells from Mc-induced apoptosis. Finally, Mc suppressed cell proliferation and induced cell death in vivo in a xenograft PC3 tumor mouse model. These findings demonstrate that Mc is a novel SENP1 inhibitor with potential therapeutic value for PCa. Investigation of other pentacyclic triterpenoids may aid in the development of novel SENP1 inhibitor drugs. |
| 关键词 | Momordin Ic Senp1 Sumoylation Proliferation Prostate Cancer |
| DOI | 10.18632/oncotarget.10636 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387153900021 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33665 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Clin Lab, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Chem Biol Div,Sch Med,Shanghai Univ E Inst, Key Lab Cell Differentiat & Apoptosis,Fac Basic M, Chinese Minist Educ,Hongqiao Int Inst Med,Shangha, Shanghai, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jingjing,Lei, Hu,Zhang, Jinfu,et al. Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation[J]. ONCOTARGET,2016,7(37):58995-59005. |
| APA | Wu, Jingjing.,Lei, Hu.,Zhang, Jinfu.,Chen, Xiangyun.,Tang, Caixia.,...&Wu, Yingli.(2016).Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation.ONCOTARGET,7(37),58995-59005. |
| MLA | Wu, Jingjing,et al."Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation".ONCOTARGET 7.37(2016):58995-59005. |
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