| New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production | |
Li, Yu-Peng1,2,3; Zhao, Si-Meng4; Xu, Jun-Ju1; Zeng, Guang-Zhi4; Li, Yan4 ; Tan, Ning-Hua4; Yang, Ye5
| |
| 2016 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
 |
| 卷号 | 30期号:23页码:2669-2674 |
| 摘要 | Two new labdane diterpenes, hedychenoids A (1) and B (2), were isolated from the rhizomes of Hedychium yunnanense, together with four known ones hedychenone (3), forrestin A (4), villosin (5) and calcaratarin C (6). Their structures were determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. Compounds 2, 3 and 5 exhibited cytotoxicity against SGC-7901 with IC50 values of 14.88 +/- 0.52, 7.08 +/- 0.21 and 7.76 +/- 0.21g/ml, 3 and 5 against HeLa with IC50 values of 9.76 +/- 0.48 and13.24 +/- 0.63g/ml, respectively. Compounds 2, 5 showed inhibitory effects against nitric oxide production in LPS and IFN--induced RAW 264.7 murine macrophages with IC50 values of 6.57 +/- 0.88 and 5.99 +/- 1.20g/ml, respectively. |
| 关键词 | Zingiberaceae Hedychium Yunnanense Labdane Diterpenes Inhibition Of No Production Cytotoxicity |
| DOI | 10.1080/14786419.2016.1143829 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387296400007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33661 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Agr Univ, Yunnan Res Ctr Good Agr Practice Dominant Chinese, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 5.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yu-Peng,Zhao, Si-Meng,Xu, Jun-Ju,et al. New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production[J]. NATURAL PRODUCT RESEARCH,2016,30(23):2669-2674. |
| APA | Li, Yu-Peng.,Zhao, Si-Meng.,Xu, Jun-Ju.,Zeng, Guang-Zhi.,Li, Yan.,...&Yang, Ye.(2016).New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production.NATURAL PRODUCT RESEARCH,30(23),2669-2674. |
| MLA | Li, Yu-Peng,et al."New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production".NATURAL PRODUCT RESEARCH 30.23(2016):2669-2674. |
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