Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases
Zhu, Hong-Jie1,2; Yan, Yong-Ming2; Tu, Zheng-Chao3; Luo, Jin-Feng3; Liang, Rui3; Yang, Tong-Hua4; Cheng, Yong-Xian2; Wang, Shu-Mei1
2016-10-01
Source PublicationFITOTERAPIA
Volume114Pages:163-167
AbstractPlancyamides A (1) and B (3), plancypyrazine A (2), and plancyols A (4) and B (5), five new compounds (1-5), and three known ones (6-8), were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were elucidated by a combination of spectroscopic analyses including 1D and 2D NMR, and HRESIMS. Among them, compound 3 is racemic, chiral HPLC separation afforded its respective enantiomers. The absolute configuration of 1 was assigned by computational methods. Biological evaluation of all the compounds with exception of 7 and 8 discloses that compounds 2 and 4 could inhibit JAK3 kinase with IC50 values of 12.6 and 5.0 mu M, respectively. In addition, compound 4 exhibit inhibitory activity towards DDR1 kinase with IC50 value of 4.87 mu M. (C) 2016 Elsevier B.V. All rights reserved.
KeywordPolyphaga Plancyi Bolivar Insect Computational Methods Jak3 Ddr1
DOI10.1016/j.fitote.2016.09.005
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000386643600023
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33654
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
4.First Peoples Hosp Yunnan Prov, Dept Hematol, Kunming 650032, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Hong-Jie,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases[J]. FITOTERAPIA,2016,114:163-167.
APA Zhu, Hong-Jie.,Yan, Yong-Ming.,Tu, Zheng-Chao.,Luo, Jin-Feng.,Liang, Rui.,...&Wang, Shu-Mei.(2016).Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases.FITOTERAPIA,114,163-167.
MLA Zhu, Hong-Jie,et al."Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases".FITOTERAPIA 114(2016):163-167.
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