Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases

doi:10.1016/j.fitote.2016.09.005

	Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases
	Zhu, Hong-Jie 1,2; Yan, Yong-Ming 2; Tu, Zheng-Chao 3; Luo, Jin-Feng 3; Liang, Rui 3; Yang, Tong-Hua 4; Cheng, Yong-Xian 2; Wang, Shu-Mei 1
	2016-10-01
发表期刊	FITOTERAPIA
卷号	114 页码:163-167
摘要	Plancyamides A (1) and B (3), plancypyrazine A (2), and plancyols A (4) and B (5), five new compounds (1-5), and three known ones (6-8), were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were elucidated by a combination of spectroscopic analyses including 1D and 2D NMR, and HRESIMS. Among them, compound 3 is racemic, chiral HPLC separation afforded its respective enantiomers. The absolute configuration of 1 was assigned by computational methods. Biological evaluation of all the compounds with exception of 7 and 8 discloses that compounds 2 and 4 could inhibit JAK3 kinase with IC50 values of 12.6 and 5.0 mu M, respectively. In addition, compound 4 exhibit inhibitory activity towards DDR1 kinase with IC50 value of 4.87 mu M. (C) 2016 Elsevier B.V. All rights reserved.
关键词	Polyphaga Plancyi Bolivar Insect Computational Methods Jak3 Ddr1
DOI	10.1016/j.fitote.2016.09.005
收录类别	SCI
语种	英语
WOS记录号	WOS:000386643600023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/33654
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 4.First Peoples Hosp Yunnan Prov, Dept Hematol, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Hong-Jie,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases[J]. FITOTERAPIA,2016,114:163-167.
APA	Zhu, Hong-Jie.,Yan, Yong-Ming.,Tu, Zheng-Chao.,Luo, Jin-Feng.,Liang, Rui.,...&Wang, Shu-Mei.(2016).Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases.FITOTERAPIA,114,163-167.
MLA	Zhu, Hong-Jie,et al."Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases".FITOTERAPIA 114(2016):163-167.

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