| Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry | |
Cao, Min-Min1,3,4; Wang, Dan5,6; Zhang, Hao1; Fang, Dong-Mei2; He, Hong-Ping1,2,3; Hao, Xiao-Jiang3 ; Zhang, Guo-Lin2; Wu, Zhi-Jun2
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| 2016 | |
| 发表期刊 | CURRENT PHARMACEUTICAL ANALYSIS
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| 卷号 | 12期号:3页码:249-257 |
| 摘要 | A series of 16 Daphniphyllum alkaloids isolated from Daphniphyllum macropodum were investigated by electrospray ionization quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS) in positive-ion mode. Deuterium labeling experiments were carried out to identify the major product ions. Although compounds have similar structures, the profiles of their MS/MS spectra vary greatly. For compounds 1 and 2, abundant product ions both in high and low mass range can be detected. A six-member H rearrangement and the cleavage of C1-C2 bond connecting rings A, C and D play an important role in providing the product ions in low mass range. For compounds 3-9, the relative abundance of product ions in low mass range is low. This may result from the loss of HCOOCH3 occurring readily because C4-C5 double bond prevents six-member H rearrangement. Main fragmentation patterns of compounds 10-14 are the loss of the different side-chain groups and the cleavage of pyrrol and pyridine rings. A series of ion clusters detected in low mass range are characteristic ions for compounds 10-14. Fragmentation patterns of compounds 15 and 16 were elucidated. Four groups of isomers in these compounds were distinguished by characteristic product ions or fragmentation patterns. |
| 关键词 | Daphniphyllum Alkaloids Electrospray Esi-qtof Six-member h Rearrangement Fragmentation Isomers |
| DOI | 10.2174/1573412911666151022203917 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000384722100012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33617 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Pharm, TCM, Kunming, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Box 610041, Chengdu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 4.Univ Chinese Acad Sci Beijing, Beijing, Peoples R China 5.Chengdu Univ, Chengdu, Peoples R China 6.Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Min-Min,Wang, Dan,Zhang, Hao,et al. Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry[J]. CURRENT PHARMACEUTICAL ANALYSIS,2016,12(3):249-257. |
| APA | Cao, Min-Min.,Wang, Dan.,Zhang, Hao.,Fang, Dong-Mei.,He, Hong-Ping.,...&Wu, Zhi-Jun.(2016).Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry.CURRENT PHARMACEUTICAL ANALYSIS,12(3),249-257. |
| MLA | Cao, Min-Min,et al."Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry".CURRENT PHARMACEUTICAL ANALYSIS 12.3(2016):249-257. |
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| D0014PA.pdf（472KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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