Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry
Cao, Min-Min1,3,4; Wang, Dan5,6; Zhang, Hao1; Fang, Dong-Mei2; He, Hong-Ping1,2,3; Hao, Xiao-Jiang3; Zhang, Guo-Lin2; Wu, Zhi-Jun2
2016
Source PublicationCURRENT PHARMACEUTICAL ANALYSIS
Volume12Issue:3Pages:249-257
AbstractA series of 16 Daphniphyllum alkaloids isolated from Daphniphyllum macropodum were investigated by electrospray ionization quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS) in positive-ion mode. Deuterium labeling experiments were carried out to identify the major product ions. Although compounds have similar structures, the profiles of their MS/MS spectra vary greatly. For compounds 1 and 2, abundant product ions both in high and low mass range can be detected. A six-member H rearrangement and the cleavage of C1-C2 bond connecting rings A, C and D play an important role in providing the product ions in low mass range. For compounds 3-9, the relative abundance of product ions in low mass range is low. This may result from the loss of HCOOCH3 occurring readily because C4-C5 double bond prevents six-member H rearrangement. Main fragmentation patterns of compounds 10-14 are the loss of the different side-chain groups and the cleavage of pyrrol and pyridine rings. A series of ion clusters detected in low mass range are characteristic ions for compounds 10-14. Fragmentation patterns of compounds 15 and 16 were elucidated. Four groups of isomers in these compounds were distinguished by characteristic product ions or fragmentation patterns.
KeywordDaphniphyllum Alkaloids Electrospray Esi-qtof Six-member h Rearrangement Fragmentation Isomers
DOI10.2174/1573412911666151022203917
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000384722100012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33617
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Pharm, TCM, Kunming, Peoples R China
2.Chinese Acad Sci, Chengdu Inst Biol, Box 610041, Chengdu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
4.Univ Chinese Acad Sci Beijing, Beijing, Peoples R China
5.Chengdu Univ, Chengdu, Peoples R China
6.Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China
Recommended Citation
GB/T 7714
Cao, Min-Min,Wang, Dan,Zhang, Hao,et al. Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry[J]. CURRENT PHARMACEUTICAL ANALYSIS,2016,12(3):249-257.
APA Cao, Min-Min.,Wang, Dan.,Zhang, Hao.,Fang, Dong-Mei.,He, Hong-Ping.,...&Wu, Zhi-Jun.(2016).Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry.CURRENT PHARMACEUTICAL ANALYSIS,12(3),249-257.
MLA Cao, Min-Min,et al."Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry".CURRENT PHARMACEUTICAL ANALYSIS 12.3(2016):249-257.
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